Pharmacokinetics, Pharmacodynamics and Safety Study of Z-213 to Iron Deficiency Anemia

NCT ID: NCT02170311

Last Updated: 2015-03-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

24 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-06-30

Study Completion Date

2015-03-31

Brief Summary

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The safety, tolerability, pharmacokinetics and pharmacodynamics of Z-213 will be investigated in patients with iron-deficiency anemia after administration of a single dose (100 mg, 500 mg, 800 mg or 1,000 mg iron).

Detailed Description

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Conditions

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Iron Deficiency Anemia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Z-213 100mg

Group/Cohort Label: 100 mg iron Z-213 will be administered by intravenous infusion.

Group Type EXPERIMENTAL

Z-213

Intervention Type DRUG

Z-213 500mg

Group/Cohort Label: 500 mg iron Z-213 will be administered by intravenous infusion.

Group Type EXPERIMENTAL

Z-213

Intervention Type DRUG

Z-213 800mg

Group/Cohort Label: 800 mg iron Z-213 will be administered by intravenous infusion.

Group Type EXPERIMENTAL

Z-213

Intervention Type DRUG

Z-213 1000mg

Group/Cohort Label: 1000 mg iron Z-213 will be administered by intravenous infusion.

Group Type EXPERIMENTAL

Z-213

Intervention Type DRUG

Interventions

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Z-213

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patients with mild iron deficiency anemia

Exclusion Criteria

* Patients with anemia caused by conditions other than iron deficiency
* Patients with abnormal laboratory test values at screening for C-reactive protein, Serum phosphorus, Aspartate aminotransferase, Alanine aminotransferase, Total bilirubin
* Patients with liver, kidney or circulatory system disease
* Patients with a history or present illness that is a malignant tumor or autoimmune disease
* Patients who underwent intravenous administration of an iron preparation, administration of an erythropoiesis stimulation agent or blood transfusion within 8 weeks before the screening
* Patients who underwent oral administration of an iron preparation (including an over-the-counter drug or supplement) within 4 weeks before the screening
Minimum Eligible Age

18 Years

Maximum Eligible Age

64 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Zeria Pharmaceutical

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Zeria Investigator

Role: STUDY_DIRECTOR

Zeria Pharmaceutical Co., Ltd

Locations

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Zeria Investigative Site

Tokyo, , Japan

Site Status

Countries

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Japan

Other Identifiers

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Z213-01

Identifier Type: -

Identifier Source: org_study_id

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