Effects of 5-Aminolevulinic Acid on Iron Deficiency Anemia

NCT ID: NCT01380548

Last Updated: 2013-03-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

135 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-06-30

Study Completion Date

2012-12-31

Brief Summary

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This study is designed to evaluate efficacy and dose-dependency of 5-aminolevulinic acid in subjects with iron deficiency anemia.

Detailed Description

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Conditions

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Iron Deficiency Anemia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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Placebo

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DIETARY_SUPPLEMENT

Placebo; once/day; for 12 weeks

Iron alone

Group Type PLACEBO_COMPARATOR

Iron alone

Intervention Type DIETARY_SUPPLEMENT

Iron (3 mg); once/day; for 12 weeks

Low-dose 5-aminolevulinic acid

Group Type EXPERIMENTAL

Low-dose 5-aminolevulinic acid with iron

Intervention Type DIETARY_SUPPLEMENT

5-Aminolevulinic acid (12.5 mg) and iron (3 mg); once/day; for 12 weeks

Medium-dose 5-aminolevulinic acid

Group Type EXPERIMENTAL

Medium-dose 5-aminolevulinic acid with iron

Intervention Type DIETARY_SUPPLEMENT

5-Aminolevulinic acid (25 mg) and iron (3 mg); once/day; for 12 weeks

High-dose 5-aminolevulinic acid

Group Type EXPERIMENTAL

High-dose 5-aminolevulinic acid with iron

Intervention Type DIETARY_SUPPLEMENT

5-Aminolevulinic acid (50 mg) and iron (3 mg); once/day; for 12 weeks

Interventions

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Placebo

Placebo; once/day; for 12 weeks

Intervention Type DIETARY_SUPPLEMENT

Iron alone

Iron (3 mg); once/day; for 12 weeks

Intervention Type DIETARY_SUPPLEMENT

Low-dose 5-aminolevulinic acid with iron

5-Aminolevulinic acid (12.5 mg) and iron (3 mg); once/day; for 12 weeks

Intervention Type DIETARY_SUPPLEMENT

Medium-dose 5-aminolevulinic acid with iron

5-Aminolevulinic acid (25 mg) and iron (3 mg); once/day; for 12 weeks

Intervention Type DIETARY_SUPPLEMENT

High-dose 5-aminolevulinic acid with iron

5-Aminolevulinic acid (50 mg) and iron (3 mg); once/day; for 12 weeks

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Premenopausal women with hemoglobin ≥ 9.0 g/dl and ≤ 12.0 g/dl
* Willing not to donate blood during the study
* Informed consent signed

Exclusion Criteria

* History of porphyria, hemochromatosis, or viral hepatitis
* Anemia other than iron deficiency
* BMI ≤ 18 kg/m2 or ≥ 30 kg/m2
* Pregnant or nursing a child
* Participation in any clinical trial within 90 days of the commencement of the trial
* Renal or hepatic dysfunction
* Heart disease
* Subjects who are taking medicines or functional food that may affect hemoglobin level
Minimum Eligible Age

20 Years

Maximum Eligible Age

49 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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SBI ALApromo Co., Ltd., Japan

UNKNOWN

Sponsor Role collaborator

Hiroshima University

OTHER

Sponsor Role lead

Responsible Party

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Fumiko Higashikawa

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Hiroshima University

Hiroshima, , Japan

Site Status

Countries

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Japan

Other Identifiers

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eki-396

Identifier Type: -

Identifier Source: org_study_id

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