A Trial Comparing Ferumoxytol With Placebo for the Treatment of Iron Deficiency Anemia

NCT ID: NCT01114139

Last Updated: 2022-04-21

Study Results

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

812 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-06-19

Study Completion Date

2012-10-22

Brief Summary

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To evaluate the efficacy and safety of intravenous (IV) ferumoxytol compared with placebo for the treatment of iron deficiency anemia (IDA).

Detailed Description

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This Phase III, randomized, double-blind, placebo-controlled, multicenter clinical study evaluated the safety and efficacy of ferumoxytol compared with placebo for the treatment of IDA, specifically in adult patients with IDA who have a history of unsatisfactory oral iron therapy or in whom oral iron could not be used. The effect of ferumoxytol on hemoglobin, iron parameters and patient reported outcomes (PROs) compared with placebo was evaluated. Investigators were blinded to key laboratory parameters that could potentially unblind the treatment arms of the study, eg, hemoglobin \[Hgb\], hematocrit \[Hct\], iron, ferritin, total iron binding capacity \[TIBC\], and transferrin saturation \[TSAT\], and neither the Investigators nor the subjects were aware of their treatment assignment, hemoglobin or other laboratory values.

Conditions

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Iron Deficiency Anemia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Ferumoxytol

Participants received a total of 2 doses of IV ferumoxytol 510 milligrams (mg) (17 milliliters \[mL\]). The first IV 510 mg dose was administered on Day 1 (Baseline) and second dose 2 to 8 (5±3) days after the first dose, for a total cumulative dose of 1.02 grams (g).

Group Type EXPERIMENTAL

Ferumoxytol

Intervention Type DRUG

IV Ferumoxytol

Placebo

Participants received a total of 2 doses of IV saline (17 mL). The first IV dose was administered on Day 1 (Baseline) and second dose 2 to 8 (5±3) days after the first dose.

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type OTHER

IV Placebo

Interventions

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Ferumoxytol

IV Ferumoxytol

Intervention Type DRUG

Placebo

IV Placebo

Intervention Type OTHER

Other Intervention Names

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Feraheme

Eligibility Criteria

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Inclusion Criteria

1. Males and females ≥18 years of age
2. Participants with IDA defined as having:

1. Hemoglobin \<10.0 g/deciliter (dL)
2. Transferrin saturation \<20%
3. Participants who have a history of unsatisfactory oral iron therapy or in whom oral iron cannot be used
4. Female participants of childbearing potential who are sexually active must be on an effective method of birth control for at least 1 month prior to screening and agree to remain on birth control until completion of participation in the study

Exclusion Criteria

1. History of allergy to IV iron
2. Allergy to two or more classes of drugs
3. Participants on dialysis or with an estimated glomerular filtration rate \<30 mL/minute/1.73 m\^2
4. Female participants who are pregnant, intend to become pregnant, are breastfeeding, within 2 weeks postpartum, or have a positive serum/urine pregnancy test
5. Hemoglobin ≤7.0 g/dL
6. Serum ferritin \>600 nanograms/mL
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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AMAG Pharmaceuticals, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Birmingham, Alabama, United States

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Mobile, Alabama, United States

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Montgomery, Alabama, United States

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Montgomery, Alabama, United States

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Green Valley, Arizona, United States

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Phoenix, Arizona, United States

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Phoenix, Arizona, United States

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Tucson, Arizona, United States

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Tucson, Arizona, United States

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Alhambra, California, United States

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Anaheim, California, United States

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Bakersfield, California, United States

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Buena Park, California, United States

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Colton, California, United States

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Fresno, California, United States

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Glendale, California, United States

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Laguna Hills, California, United States

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Laguna Hills, California, United States

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Lakewood, California, United States

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Los Angeles, California, United States

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Los Angeles, California, United States

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Los Angeles, California, United States

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Mission Hills, California, United States

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Orange, California, United States

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San Diego, California, United States

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San Diego, California, United States

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San Diego, California, United States

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Pueblo, Colorado, United States

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Bristol, Connecticut, United States

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Groton, Connecticut, United States

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Newark, Delaware, United States

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Boynton Beach, Florida, United States

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Boynton Beach, Florida, United States

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Clearwater, Florida, United States

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Clearwater, Florida, United States

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Hialeah, Florida, United States

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Holiday, Florida, United States

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Inverness, Florida, United States

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Margate, Florida, United States

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Miami, Florida, United States

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Miami, Florida, United States

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Miami, Florida, United States

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Miami, Florida, United States

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Miami, Florida, United States

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Miami Lakes, Florida, United States

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Naples, Florida, United States

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Ocala, Florida, United States

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Vero Beach, Florida, United States

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Wellington, Florida, United States

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Wellington, Florida, United States

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West Palm Beach, Florida, United States

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Winter Park, Florida, United States

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Zephyrhills, Florida, United States

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Atlanta, Georgia, United States

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Atlanta, Georgia, United States

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Atlanta, Georgia, United States

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Columbus, Georgia, United States

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Decatur, Georgia, United States

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Dublin, Georgia, United States

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Rome, Georgia, United States

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Sandy Springs, Georgia, United States

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Savannah, Georgia, United States

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Stockbridge, Georgia, United States

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Aurora, Illinois, United States

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Chicago, Illinois, United States

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Chicago, Illinois, United States

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Evergreen Park, Illinois, United States

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Skokie, Illinois, United States

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Skokie, Illinois, United States

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Springfield, Illinois, United States

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Indianapolis, Indiana, United States

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Wichita, Kansas, United States

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New Orleans, Louisiana, United States

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Bethesda, Maryland, United States

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Hollywood, Maryland, United States

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Prince Frederick, Maryland, United States

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AMAG Pharmaceuticals, Inc.

Waltham, Massachusetts, United States

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Bay City, Michigan, United States

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Bay City, Michigan, United States

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Saginaw, Michigan, United States

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Wyoming, Michigan, United States

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Kansas City, Missouri, United States

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Las Vegas, Nevada, United States

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Lawrenceville, New Jersey, United States

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Neptune City, New Jersey, United States

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Plainsboro, New Jersey, United States

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Somerville, New Jersey, United States

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Voorhees Township, New Jersey, United States

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Albuquerque, New Mexico, United States

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Brooklyn, New York, United States

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Goshen, New York, United States

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New York, New York, United States

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New York, New York, United States

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Raleigh, North Carolina, United States

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Wilmington, North Carolina, United States

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Winston-Salem, North Carolina, United States

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Bismarck, North Dakota, United States

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Akron, Ohio, United States

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Beavercreek, Ohio, United States

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Canton, Ohio, United States

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Carlisle, Ohio, United States

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Cincinnati, Ohio, United States

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Cincinnati, Ohio, United States

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Columbus, Ohio, United States

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Dayton, Ohio, United States

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Marion, Ohio, United States

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Marion, Ohio, United States

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Mentor, Ohio, United States

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Middletown, Ohio, United States

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Zanesville, Ohio, United States

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Norman, Oklahoma, United States

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Jenkintown, Pennsylvania, United States

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Levittown, Pennsylvania, United States

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East Providence, Rhode Island, United States

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Columbia, South Carolina, United States

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Greer, South Carolina, United States

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Myrtle Beach, South Carolina, United States

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North Charleston, South Carolina, United States

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Orangeburg, South Carolina, United States

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Rapid City, South Dakota, United States

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Nashville, Tennessee, United States

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Arlington, Texas, United States

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Dallas, Texas, United States

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Houston, Texas, United States

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Houston, Texas, United States

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Houston, Texas, United States

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Laredo, Texas, United States

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Longview, Texas, United States

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San Antonio, Texas, United States

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San Antonio, Texas, United States

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San Antonio, Texas, United States

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San Antonio, Texas, United States

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San Antonio, Texas, United States

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Spring, Texas, United States

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Orem, Utah, United States

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Chesapeake, Virginia, United States

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Norfolk, Virginia, United States

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Vancouver, British Columbia, Canada

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Saint John, New Brunswick, Canada

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London, Ontario, Canada

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Scarborough Village, Ontario, Canada

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Thornhill, Ontario, Canada

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Vaughan, Ontario, Canada

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Pointe-Claire, Quebec, Canada

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Békéscsaba, , Hungary

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Gyula, , Hungary

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Komárom, , Hungary

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Szekszárd, , Hungary

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Vác, , Hungary

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Hyderabad, Andhra Pradesh, India

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Secunderabad, Andhra Pradesh, India

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Visakhapatnam, Andhrapradesh, India

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Guwahati, Assam, India

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Bangalore, Karnataka, India

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Bangalore, Karnataka, India

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Mangalore, Karnataka, India

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Aurangabad, Maharashtra, India

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Nagpur, Maharashtra, India

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Nashik, Maharashtra, India

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Pune, Maharashtra, India

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Jaipur, Rajasthan, India

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Jaipur, Rajasthan, India

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Chennai, Tamil Nadu, India

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Chennai, Tamil Nadu, India

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Coimbatore, Tamil Nadu, India

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Madurai, Tamil Nadu, India

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Lucknow, Uttar Pradesh, India

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Lucknow, Uttar Pradesh, India

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Daugavpils, , Latvia

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Riga, , Latvia

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Riga, , Latvia

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Riga, , Latvia

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Riga, , Latvia

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Valmiera, , Latvia

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Ventspils, , Latvia

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Ventspils, , Latvia

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Bialystok, , Poland

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Sopot, , Poland

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Warsaw, , Poland

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Warsaw, , Poland

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Wroclaw, , Poland

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Zgierz, , Poland

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Countries

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United States Canada Hungary India Latvia Poland

References

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Vadhan-Raj S, Strauss W, Ford D, Bernard K, Boccia R, Li J, Allen LF. Efficacy and safety of IV ferumoxytol for adults with iron deficiency anemia previously unresponsive to or unable to tolerate oral iron. Am J Hematol. 2014 Jan;89(1):7-12. doi: 10.1002/ajh.23582. Epub 2013 Sep 30.

Reference Type BACKGROUND
PMID: 23983177 (View on PubMed)

Other Identifiers

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AMAG-FER-IDA-301

Identifier Type: -

Identifier Source: org_study_id

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