LifeVest Trends Validation Protocol

NCT ID: NCT02149290

Last Updated: 2020-08-31

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

198 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-02-28

Study Completion Date

2017-12-31

Brief Summary

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This study will evaluate the accuracy of data on body position, daily activity, heart rate, 6-minute walk test, and a health survey collected by the wearable cardioverter defibrillator (WCD).

Detailed Description

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This is a multi-center validation study of heart failure patients wearing the LifeVest WCD modified to collect data on body position, activity, heart rate, 6-minute walk test, and a health survey in order to evaluate data accuracy and patient interactions with the device.

Conditions

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Heart Failure

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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Trends-equipped LifeVest 4000

Subjects using the LifeVest 4000 modified to collect Trends data

Trends-equipped LifeVest 4000

Intervention Type DEVICE

LifeVest 4000 monitors patients for VT/VF, notifies the patient if VT/VF occurs, and instructs them to press response buttons. In unresponsive patients, LifeVest delivers defibrillation therapy. Trends modifications for heart failure monitoring include: body position data collection; heart rate measurements, activity data collection; ability to perform a health survey; ability to guide patients through a walk test

Interventions

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Trends-equipped LifeVest 4000

LifeVest 4000 monitors patients for VT/VF, notifies the patient if VT/VF occurs, and instructs them to press response buttons. In unresponsive patients, LifeVest delivers defibrillation therapy. Trends modifications for heart failure monitoring include: body position data collection; heart rate measurements, activity data collection; ability to perform a health survey; ability to guide patients through a walk test

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Symptomatic heart failure (i.e., New York Heart Association (NYHA) class II or higher)
* Evidence of a prior Myocardial Infarction (MI) or dilated cardiomyopathy
* Ejection fraction of 35% or less at the start of WCD use
* Anticipated to need a WCD for three months or more
* At least 18 years of age (over the legal age of providing consent)

Exclusion Criteria

* Use of an implantable cardioverter defibrillator (ICD), recent removal of an ICD, or planned use of an ICD within the next three months
* Need for an assistive device for ambulation (wheelchair, walker, or cane)
* Use of a unipolar pacemaker
* Physical or mental conditions that prevent interaction with or wearing of the device
* Advanced directive prohibiting resuscitation
* Pregnancy
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Zoll Medical Corporation

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Steven J Szymkiewicz, MD

Role: STUDY_DIRECTOR

Zoll Medical Corporation

Locations

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Orange County Heart Institute

Orange, California, United States

Site Status

Cardiac Arrhythmia Service

Boca Raton, Florida, United States

Site Status

Gwinnett Medical Center

Lawrenceville, Georgia, United States

Site Status

Lexington Cardiology Consultants

Lexington, Kentucky, United States

Site Status

Cardiology Institute of Michigan

Flint, Michigan, United States

Site Status

SUNY Downstate

Brooklyn, New York, United States

Site Status

Oklahoma Heart Hospital

Oklahoma City, Oklahoma, United States

Site Status

Erlanger Clinical Research

Chattanooga, Tennessee, United States

Site Status

Methodist Healthcare Foundation

Memphis, Tennessee, United States

Site Status

VA Beach General

Virginia Beach, Virginia, United States

Site Status

Swedish Medical Center

Seattle, Washington, United States

Site Status

CAMC

Charleston, West Virginia, United States

Site Status

St. Mary's Medical Center

Huntington, West Virginia, United States

Site Status

Klinische Abteilung für Kardiologie

Graz, , Austria

Site Status

Universitats-Herzzentrum Freiburg - Bad Krozingen

Bad Krozingen, , Germany

Site Status

Kerckhoff-Klinik

Bad Nauheim, , Germany

Site Status

Medizinische Klinik & Poliklinik II - Kardiologie

Bonn, , Germany

Site Status

Klinikum Coburg

Coburg, , Germany

Site Status

St. Vinzenz Hospital

Cologne, , Germany

Site Status

Department für Herzinsuffizienz und Devicetherap

Hamburg, , Germany

Site Status

Klinik für Innere Medizin III

Villingen-Schwenningen, , Germany

Site Status

Countries

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United States Austria Germany

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

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90D0120

Identifier Type: -

Identifier Source: org_study_id

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