Radial Artery Function Following Trans-radial Cardiac Catheterisation

NCT ID: NCT02147119

Last Updated: 2017-04-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

5 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-03-31

Study Completion Date

2015-12-31

Brief Summary

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The investigators will study Radial artery injury and endothelial function following trans-radial cardiac catheterisation. Radial artery injury will be quantified pre- and post- angiography using Optical Coherence Tomography. The participants will also have radial endothelial function assessed using flow-mediated dilatation at baseline, 24 hours, one week, one month and three months post- angiography. Blood will be taken pre and 24 hours post angiography for characterisation of endothelial progenitor cell numbers and function. The hypothesis is that trans-radial catheterisation will cause a reduction in flow-mediated dilatation which peaks at 24 hours and recovers at three months. The investigators hope to correlate the rate of this recovery with peri-procedural progenitor cell numbers.

Detailed Description

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Conditions

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Atherosclerosis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Patients post- cardiac catheterisation

Coronary angiography

Intervention Type PROCEDURE

Interventions

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Coronary angiography

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Stable outpatient population aged between 18-85 attending for trans-radial cardiac catheterisation

Exclusion Criteria

* Recent myocardial infarction (\<3 months)
* Severe aortic stenosis
* Chronic renal failure (eGFR\<30)
* Inability to give informed consent
Minimum Eligible Age

18 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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British Heart Foundation

OTHER

Sponsor Role collaborator

University of Edinburgh

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Andrew J Mitchell, MBChB

Role: PRINCIPAL_INVESTIGATOR

University of Edinburgh

Locations

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Clinical research facility University Royal Infirmary of Edinburgh

Edinburgh, Midlothian, United Kingdom

Site Status

Countries

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United Kingdom

References

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Mitchell A, Fujisawa T, Mills NL, Brittan M, Newby DE, Cruden NLM. Endothelial Progenitor Cell Biology and Vascular Recovery Following Transradial Cardiac Catheterization. J Am Heart Assoc. 2017 Oct 28;6(11):e006610. doi: 10.1161/JAHA.117.006610.

Reference Type DERIVED
PMID: 29080864 (View on PubMed)

Other Identifiers

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PG13/32/30205

Identifier Type: -

Identifier Source: org_study_id

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