Healthy Age-dependent Reference Values for Microvascular Structure and Function

NCT ID: NCT04897191

Last Updated: 2021-05-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-05-18

Study Completion Date

2021-08-31

Brief Summary

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The greatest challenge in our ageing society are cardiovascular diseases such as stroke, heart attack, peripheral artery disease of the legs with non-healing wounds (ulcers), or diabetes. How healthy ageing affects the smallest blood vessels (microcirculation) and is not well understood. One reason for this is that no generally available medical instrument has the resolution to study the microcirculation. The recently developed optical coherence tomography angiography (OCTA), currently mainly used by eye doctors, is able to visualise the microcirculation. We have developed an automated software (OCTAVA) to determine metrics to characterise the microcirculation on the layers of density, diameter and tortuosity.

In the current study we aim at providing reference values of these metrics in hands and feet of healthy people according to age together with macrovascular function in arms and legs.

Detailed Description

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Conditions

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Vascular Endothelium Microvascular Circulation Arterial Stiffness Healthy Ageing

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Healthy

Healthy people age 20-70 years

Age

Intervention Type OTHER

Determination of age-dependence

Interventions

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Age

Determination of age-dependence

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

Healthy, 20-70 years, BMI 20-30 kg/m\^2

Exclusion Criteria

Diabetes mellitus, symptoms of acute infection, cardiac arrhythmias, active malignancy, clinical signs or symptoms of cardiovascular disease (coronary artery disease, lower extremity artery disease, cerebrovascular disease): angina pectoris, dyspnea, palpitation, syncope, claudication, active vasoactive medication.
Minimum Eligible Age

20 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Surrey

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Christian Heiss, Prof.

Role: PRINCIPAL_INVESTIGATOR

University of Surrey

Locations

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University of Surrey

Guildford, , United Kingdom

Site Status RECRUITING

Countries

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United Kingdom

Central Contacts

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Christian Heiss, Prof.

Role: CONTACT

+441737231749

Danuta Sampson, Dr.

Role: CONTACT

Facility Contacts

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Mariam Bapir

Role: primary

Other Identifiers

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OCTA1

Identifier Type: -

Identifier Source: org_study_id

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