Assessment of Coronary Artery Lesion Using Optical Coherence Tomography Versus IntraVascular Ultrasound for BiorEsorbable Vascular Scaffold Implantation

NCT ID: NCT02814578

Last Updated: 2018-09-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

9 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-07-31

Study Completion Date

2017-07-31

Brief Summary

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The primary objective is to determine whether IVUS- (vs. OCT-) guided BVS implantation is non-inferior to achieve a large in-scaffold minimal lumen area (primary endpoint) measured by OCT at 1-year follow-up.

Detailed Description

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Conditions

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Coronary Artery Disease

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Optical coherent tomography

Optical coherent tomography provides more detailed information about the morphology of scaffolds, microstructures and coronary vasculature based on tissue characteristics as compared to conventional IVUS. In spite of angiographic success in BVS placement, further scaffold optimization was required in over a quarter of cases based on OCT findings due to malapposition or scaffold under expansion.

Group Type EXPERIMENTAL

Optical coherent tomography

Intervention Type OTHER

comparative method for BVS

IntraVascular UltraSound

Intravascular ultrasound guidance has been associated with improved event-free survival compared with angiographic guidance after DES placement.

Group Type ACTIVE_COMPARATOR

IntraVascular UltraSound

Intervention Type OTHER

The method of goldstandard for decision stent choice

Interventions

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Optical coherent tomography

comparative method for BVS

Intervention Type OTHER

IntraVascular UltraSound

The method of goldstandard for decision stent choice

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Age 20 years or older
* Patients who have at least one epicardial coronary artery lesion with an evidence of inducible ischemia
* Willing and able to provide informed written consent
* Eligible for PCI

Exclusion Criteria

* Patients presenting with STEMI within 2 weeks
* Bypass graft lesion
* Lesion with left main disease
* Expected length of scaffold \> 40 mm
* Bifurcation lesion requiring side branch stenting
* Small vessels \< 2.75 mm
* Stented lesion
* Suspected coronary spasm even after sufficient nitrate injected
* Cases in which the IVUS or OCT imaging catheter failed to cross the lesion
* Poor quality IVUS or OCT images
* Contraindication to dual anti-platelet therapy
* Chronic total occlusion
* Angiographically large-sized vessel (\>3.5mm of reference lumen diameter)
* Life expectancy shorter than 2 years
* Pregnancy
Minimum Eligible Age

20 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Abbott Medical Devices

INDUSTRY

Sponsor Role collaborator

Young-Hak Kim, MD, PhD

OTHER

Sponsor Role lead

Responsible Party

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Young-Hak Kim, MD, PhD

Professor in medicine

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Asan Medical Center

Seoul, Songpa-Gu, South Korea

Site Status

Pusan National University Hospital

Pusan, , South Korea

Site Status

Ulsan University Hospital

Ulsan, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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AMCCV2016-02

Identifier Type: -

Identifier Source: org_study_id

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