Optical Coherence Tomography And NEphropathy: The OCTANE Study
NCT ID: NCT02132741
Last Updated: 2025-05-07
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
150 participants
OBSERVATIONAL
2014-05-16
2028-09-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Treated hypertension
Patients on treatment for hypertension
No interventions assigned to this group
CKD-ESRD
Pre- \& post haemodialysis
No interventions assigned to this group
Healthy individuals
Healthy volunteers
No interventions assigned to this group
Chronic kidney disease
Pre-dialysis CKD \& those with a functional renal transplant
No interventions assigned to this group
Hypertension
Untreated
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Age 18-80
* Body mass index ≤35
* For those with hypertension: BP ≥140/90 or on treatment for hypertension
* For those with CKD: CKD as defined by the Kidney Diseases Quality Initiative guidelines
Exclusion Criteria
* The subject has donated blood (450 ml) within the last 4 weeks
* Past or present drug or alcohol abuse including intravenous drug abuse at any time
* Participation in another clinical trial within 1 month
* Considered to be at high risk of HIV or hepatitis B
* Patients with known eye disease, or previous eye surgery, or refractive error greater than +/- 6 dioptres.
18 Years
80 Years
ALL
Yes
Sponsors
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University of Edinburgh
OTHER
Responsible Party
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Principal Investigators
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Neeraj Dhaun, MD PhD
Role: PRINCIPAL_INVESTIGATOR
University of Edinburgh
Locations
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University of Edinburgh
Edinburgh, Midlothian, United Kingdom
Countries
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Central Contacts
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References
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Balmforth C, van Bragt JJ, Ruijs T, Cameron JR, Kimmitt R, Moorhouse R, Czopek A, Hu MK, Gallacher PJ, Dear JW, Borooah S, MacIntyre IM, Pearson TM, Willox L, Talwar D, Tafflet M, Roubeix C, Sennlaub F, Chandran S, Dhillon B, Webb DJ, Dhaun N. Chorioretinal thinning in chronic kidney disease links to inflammation and endothelial dysfunction. JCI Insight. 2016 Dec 8;1(20):e89173. doi: 10.1172/jci.insight.89173.
Other Identifiers
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14/SS/0069
Identifier Type: -
Identifier Source: org_study_id
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