A Study to Evaluate Quality of Life in Patients Switched to Solifenacin From Other Antimuscarinics

NCT ID: NCT02087098

Last Updated: 2016-09-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

2000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-06-30

Study Completion Date

2016-03-31

Brief Summary

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This is a 12 month non-interventional study with solifenacin succinate, evaluating the effect of solifenacin on quality of life (QoL) of patients previously treated with antimuscarinics (Males and Females with Overactive Bladder (OAB) symptoms withdrawing their treatment with antimuscarinics because of safety and/or efficacy reasons) - measured by Perception of Treatment Satisfaction (TS-VAS) and to evaluate the effect of solifenacin on quality of life measured by Over Active Bladder-q Short Form (OAB-q SF), EuroQol Group scoring system (EQ-5D-5L).

Detailed Description

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Conditions

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Urinary Bladder, Overactive

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Patients with residual OAB symptoms

Urge urinary incontinence, urgency, and frequency after treatment with other antimuscarinics

Solifenacin

Intervention Type DRUG

Patients with residual OAB symptoms (urge urinary incontinence, urgency, and frequency) after treatment with other antimuscarinics

Interventions

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Solifenacin

Patients with residual OAB symptoms (urge urinary incontinence, urgency, and frequency) after treatment with other antimuscarinics

Intervention Type DRUG

Other Intervention Names

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Vesicare

Eligibility Criteria

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Inclusion Criteria

* Patient willing and able to complete the questionnaires
* Diagnosis of OAB
* Previous unsuccessful OAB medication (antimuscarinic treatment for at least 1 month) less than 4 weeks ago defined by:

* number of micturitions \> 8/24 h or
* decrease in urgency urinary incontinence (UUI) or incontinence episodes / 24 h less than 50% or
* decrease in urgency episodes / 24 h less than 50% or
* decrease in number of micturitions / 24 h less than 20% or
* not acceptable tolerability
* Eligible to start Vesicare™ 5 or 10 mg according to Summary of Product Characteristics (SmPC)

Exclusion Criteria

* History of stress incontinence
* Active urinary tract infection (confirmed by positive urine analysis)
* Symptoms suggestive of severe Bladder Outlet Obstruction (BOO) defined as Peak urinary flow rate (Qmax) \< 10ml/sc and/or Postvoid residual urine volume (PVR) \> 150 ml
* Uncontrolled Diabetes Mellitus
* History of drug and/or alcohol abuse at the time of enrolment
* History of acute urinary retention, severe gastrointestinal obstruction (including paralytic ileus or intestinal atony or toxic megacolon or severe ulcerative colitis), myasthenia gravis, uncontrolled narrow glaucoma or swallow anterior chamber or deemed to be at risk for these conditions.
* Undergoing hemodialysis or has severe renal impairment or moderate hepatic impairment and who are on treatment with a potent CYP3A4 inhibitor
* Previous treatment with solifenacin
* Likely to participate in another study during study period of 12 months from study entry
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Astellas Pharma Europe B.V.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Use Central Contact

Role: STUDY_DIRECTOR

Astellas Pharma Europe B.V.

Locations

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Site CZ42003 Private Practice

Benešov, , Czechia

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Site CZ42001 Private Practice

Beroun, , Czechia

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Site CZ42014 Private Practice

Blansko, , Czechia

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Site CZ42023 Private Practice

Boskovice, , Czechia

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Site CZ42032 Private Practice

Brno, , Czechia

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Site CZ42034 Hospital

Brno, , Czechia

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Site CZ42035 Private Practice

Brno, , Czechia

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Site CZ42036 Private Practice

Brno, , Czechia

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Site CZ42038 Private Practice

Brno, , Czechia

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Site CZ42039 Private Practice

Brno, , Czechia

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Site CZ42058 Hospital

Brno, , Czechia

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Site CZ42059 Hospital

Brno, , Czechia

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Site CZ42025 Private Practice

Cheb, , Czechia

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Site CZ42048 Private Practice

Dvůr Králové, , Czechia

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Site CZ42040 Private Practice

Havlíčkův Brod, , Czechia

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Site CZ42015 Private Practice

Hodonín, , Czechia

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Site CZ42045 Private Practice

Hradec Králové, , Czechia

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Site CZ42051 Private Practice

Jičín, , Czechia

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Site CZ42027 Private Practice

Jindřichŭv Hradec, , Czechia

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Site CZ42029 Private Practice

Jindřichŭv Hradec, , Czechia

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Site CZ42026 Private Practice

Karlovy Vary, , Czechia

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Site CZ42028 Private Practice

Karlovy Vary, , Czechia

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Site CZ42030 Private Practice

Klatovy, , Czechia

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Site CZ42049 Private Practice

Litoměřice, , Czechia

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Site CZ42021 Private Practice

Litovel, , Czechia

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Site CZ42050 Private Practice

Most, , Czechia

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Site CZ42054 Private Practice

Ostrava, , Czechia

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Site CZ42055 Private Practice

Ostrava, , Czechia

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Site CZ42056 Private Practice

Ostrava, , Czechia

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Site CZ42057 Private Practice

Ostrava, , Czechia

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Site CZ42005 Private Practice

Pardubice, , Czechia

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Site CZ42008 Private Practice

Pardubice, , Czechia

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Site CZ42024 Private Practice

Pilsen, , Czechia

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Site CZ42002 Private Practice

Prague, , Czechia

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Site CZ42004 Private Practice

Prague, , Czechia

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Site CZ42006 Private Practice

Prague, , Czechia

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Site CZ42007 Private Practice

Prague, , Czechia

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Site CZ42009 Private Practice

Prague, , Czechia

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Site CZ42010 Private Practice

Prague, , Czechia

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Site CZ42011 Private Practice

Prague, , Czechia

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Site CZ42060 Private Practice

Prague, , Czechia

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Site CZ42044 Private Practice

Roudnice nad Labem, , Czechia

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Site CZ42031 Private Practice

Strakonice, , Czechia

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Site CZ42020 Private Practice

Svitavy, , Czechia

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Site CZ42047 Private Practice

Teplice, , Czechia

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Site CZ42053 Private Practice

Teplice, , Czechia

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Site CZ42042 Private Practice

Trutnov, , Czechia

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Site CZ42052 Private Practice

Turnov, , Czechia

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Site CZ42018 Hospital

Uherské Hradiště, , Czechia

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Site CZ42019 Private Practice

Uherské Hradiště, , Czechia

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Site CZ42043 Private Practice

Ústí nad Labem, , Czechia

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Site CZ42046 Private Practice

Ústí nad Labem, , Czechia

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Site CZ42041 Hospital

Velké Meziříčí, , Czechia

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Site CZ42016 Private Practice

Vsetín, , Czechia

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Site CZ42017 Private Practice

Vsetín, , Czechia

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Site CZ42012 Private Practice

Zlín, , Czechia

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Site CZ42013 Private Practice

Zlín, , Czechia

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Site CZ42022 Private Practice

Zlín, , Czechia

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Site CZ42033 Private Practice

Znojmo, , Czechia

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Site CZ42037 Hospital

Znojmo, , Czechia

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Countries

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Czechia

Other Identifiers

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VEST-001

Identifier Type: -

Identifier Source: org_study_id

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