A Study to Investigate How Safe and Effective Solifenacin Solution is in Treating Children/Adolescents With Symptoms of Overactive Bladder (OAB) Who Completed Study 905-CL-076

NCT ID: NCT01655069

Last Updated: 2024-11-13

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

148 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-10-04

Study Completion Date

2014-10-08

Brief Summary

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This was a 40-week study to investigate how safe and effective solifenacin solution was in treating children or adolescents with symptoms of overactive bladder (OAB), who completed study 905-CL-076 (NCT01565707).

Detailed Description

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There was a titration period of up to 12 weeks during which the participants would be up or down-titrated based on a combination of efficacy and safety parameters followed by a fixed dose period during which no dose adjustments were allowed. Participants completed a 7-day patient diary prior to every visit (start of 905-CL-076 to end of 905-CL-077, 14 visits). The first visit of this study (905-CL-077) was combined with the last visit of the 4-month study 905-CL-076. At each visit, the participant was required to undertake a number of assessments or examinations to determine whether it is safe for him/her to take part or to continue to take part in the study.

Conditions

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Urinary Bladder, Overactive

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Children Treated with Placebo in 905-CL-076

Male and female children aged 5 to less than 12 years old who received placebo in Study 905-CL-076 and received open-label solifenacin once daily in this study. The mean time on study drug in this study was 247.9 days in children.

Group Type EXPERIMENTAL

Solifenacin succinate suspension

Intervention Type DRUG

Oral suspension

Children Treated with Solifenacin in 905-CL-076

Male and female children aged 5 to less than 12 years old who received solifenacin in Study 905-CL-076 and received open-label solifenacin once daily in this study. The mean time on study drug in this study was 247.9 days in children.

Group Type EXPERIMENTAL

Solifenacin succinate suspension

Intervention Type DRUG

Oral suspension

Adolescents Treated with Placebo in 905-CL-076

Male and female adolescents aged 12 to less than 18 years old who received placebo in Study 905-CL-076 and received open-label solifenacin once daily in this study. The mean time on study drug in this study was 240.1 days in adolescents.

Group Type EXPERIMENTAL

Solifenacin succinate suspension

Intervention Type DRUG

Oral suspension

Adolescents Treated with Solifenacin in 905-CL-076

Male and female adolescents aged 12 to less than 18 years old who received solifenacin in Study 905- CL-076 and received open-label solifenacin once daily in this study. The mean time on study drug in this study was 240.1 days in adolescents.

Group Type EXPERIMENTAL

Solifenacin succinate suspension

Intervention Type DRUG

Oral suspension

Interventions

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Solifenacin succinate suspension

Oral suspension

Intervention Type DRUG

Other Intervention Names

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YM905 solifenacin succinate

Eligibility Criteria

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Inclusion Criteria

Inclusion Criteria:

* Subject has met the inclusion criteria of study 905-CL-076 and completed study 905-CL-076

Exclusion Criteria:

* Subject has failed the exclusion criteria of study 905-CL-076
Minimum Eligible Age

5 Years

Maximum Eligible Age

17 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Astellas Pharma Europe B.V.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Clinical Study Manager

Role: STUDY_CHAIR

Astellas Pharma Europe B.V.

Locations

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Site: 1006

Shreveport, Louisiana, United States

Site Status

Site: 3202

Antwerp, , Belgium

Site Status

Site: 3209

Antwerp, , Belgium

Site Status

Site: 3208

Charleroi, , Belgium

Site Status

Site: 3201

Ghent, , Belgium

Site Status

Site: 3203

Ghent, , Belgium

Site Status

Site: 3204

Kortrijk, , Belgium

Site Status

Site: 3205

Leuven, , Belgium

Site Status

Site: 5507

Campinas, , Brazil

Site Status

Site: 5506

Curitiba, , Brazil

Site Status

Site: 1001

Québec, , Canada

Site Status

Site: 4503

Aalborg, , Denmark

Site Status

Site: 4501

Aarhus N, , Denmark

Site Status

Site: 4502

Kolding, , Denmark

Site Status

Site: 4504

Køge, , Denmark

Site Status

Site: 5202

Mexico City, , Mexico

Site Status

Site: 5205

Mexico City, , Mexico

Site Status

Site: 4701

Bergen, , Norway

Site Status

Site: 6301

Quezon City, , Philippines

Site Status

Site: 4805

Gdansk, , Poland

Site Status

Site: 4803

Gdansk, , Poland

Site Status

Site: 4804

Lubin, , Poland

Site Status

Site: 4801

Warsaw, , Poland

Site Status

Site: 3810

Belgrade, , Serbia and Montenegro

Site Status

Site: 3812

Novi Sad, , Serbia and Montenegro

Site Status

Site: 2703

Cape Town, , South Africa

Site Status

Site: 8203

Daegu, , South Korea

Site Status

Site: 8206

Incheon, , South Korea

Site Status

Site: 8207

Seoul, , South Korea

Site Status

Site: 8202

Seoul, , South Korea

Site Status

Site: 4606

Gothenburg, , Sweden

Site Status

Site: 4603

Skövde, , Sweden

Site Status

Site: 4602

Stockholm, , Sweden

Site Status

Site: 4605

Umeå, , Sweden

Site Status

Site: 9001

Ankara, , Turkey (Türkiye)

Site Status

Site: 9002

Izmir, , Turkey (Türkiye)

Site Status

Site: 3854

Kharkiv, , Ukraine

Site Status

Site: 4403

Leeds, , United Kingdom

Site Status

Site: 4401

Sheffield, , United Kingdom

Site Status

Countries

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United States Belgium Brazil Canada Denmark Mexico Norway Philippines Poland Serbia and Montenegro South Africa South Korea Sweden Turkey (Türkiye) Ukraine United Kingdom

Related Links

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Other Identifiers

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2011-002047-10

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

905-CL-077

Identifier Type: -

Identifier Source: org_study_id

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