Effectiveness of Different Interventions for Implementing Surviving Sepsis Campaign (SSC) Guidelines on Compliance and Mortality: Systematic Review and Meta-analysis

NCT ID: NCT02069028

Last Updated: 2014-02-21

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 30 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2014-02-28
• Study Completion Date: 2014-09-30

Brief Summary

This is a systematic review and Meta-Analysis of interventions for implementation of Surviving Sepsis Campaign guidelines and their impact on compliance and mortality reduction

Detailed Description

The implementation of the sepsis resuscitation bundle recommended by the SSC guidelines has been shown to increase compliance and reduce mortality in several settings. Different implementation strategies have been utilized, including education, posters, reminders, audit and feedback, paper-based and electronic sepsis screening tools, clinical pathway and sepsis response teams. Different studies showed a considerable variation effect on compliance and mortality.It has been suggested that implantation strategies vary in there effect from low impact for human-based interventions such as education and training, rules and policies, reminders, checklists and double checks, however, reaching high effect for system based interventions like automation and computerization and forcing function. However, this has not been studied in relation to the implementation of SSC bundle. As such, many projects continue to invest on low-impact interventions with modest change in compliance and mortality. Multiple interventions were adopted by different centers worldwide to implement SSC guidelines. These interventions vary on their level of compliance and outcomes. The effectiveness of intervention if system oriented is more effective than human oriented. The hierarchy of effectiveness assigning forcing function intervention on the top of the pyramid and the training and education on the bottom.

The investigators hypothesize that interventions system based interventions are more likely to be more effective in improving the compliance with sepsis resuscitation bundle and in improving mortality.

The aim of this study is to assess the effectiveness of different interventions for implementation of Surviving Sepsis Campaign guidelines and their impact on compliance and mortality reduction.

Conditions

Sepsis; Septic; Septicemia

Study Groups

Low intensity intervention

human oriented interventions with less consideration to the system based act including, but not limited to, education, training, sepsis profile and posters with protocol algorithms.

No interventions assigned to this group

Intermediate intensity intervention

interventions that lie in between human oriented and system oriented Including, but not limited to, sepsis protocols, daily audits, feedback and clinical pathway

No interventions assigned to this group

High intensity intervention

system based interventions with less involvement of human effect including, but not limited to, electronic alert systems and sepsis response team.

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

Any study or data

1. assessing any intervention method for implementing SSC guidelines in regards to compliance and mortality,

2. has a comparison group,

3. reported data on sepsis resuscitation bundle compliance and mortality

Exclusion Criteria

Any study used other than SSC guidelines in sepsis management will be excluded.

• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

King Abdullah International Medical Research Center

OTHER

Sponsor Role: lead

Responsible Party

Dr Yaseen Arabi

Chairman, Intensive Care Department, Associate Professor, King Saud Bin Abdulaziz University

Responsibility Role: PRINCIPAL_INVESTIGATOR

Other Identifiers

0

Identifier Type: -

Identifier Source: org_study_id