Multicentre LOGIC-Insulin Algorithm-guided Versus Nurse-directed Blood Glucose Control During Critical Illness (LOGIC-2)
NCT ID: NCT02056353
Last Updated: 2016-01-08
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
1550 participants
INTERVENTIONAL
2014-02-28
2015-08-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Nurse-directed
Blood glucose control guided by paper protocol
Paper protocol
LOGIC-Insulin
Blood glucose control guided by the LOGIC-Insulin algorithm
LOGIC-Insulin algorithm
Interventions
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LOGIC-Insulin algorithm
Paper protocol
Eligibility Criteria
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Inclusion Criteria
* Patients should be 18 years or older
Exclusion Criteria
* Age under 18 years
* Patients already enrolled in another intervention randomized controlled trial
* Patients expected to die within 12 hours (=moribund patients)
* No arterial line or central venous line needed
* Pregnancy or lactating
* Patients suffering from ketoacidotic or hyperosmolar coma on admission
* Patients who have been previously been included in the LOGIC-2 study
* Allergy to insulin
18 Years
ALL
No
Sponsors
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Agentschap voor Innovatie door Wetenschap en Technologie
OTHER
KU Leuven
OTHER
Responsible Party
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Greet Van den Berghe
Prof. Dr.
Principal Investigators
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Dieter Mesotten, MD, PhD
Role: STUDY_DIRECTOR
KU Leuven
Greet Van den Berghe, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
KU Leuven
Jasperina Dubois, MD
Role: PRINCIPAL_INVESTIGATOR
Jessa hospital, Hasselt
Marcus Schultz, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Locations
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Jessa Hospital
Hasselt, , Belgium
Dept Intensive Care Medicine, University Hospitals Leuven
Leuven, , Belgium
Medical Intensive Care, University Hospitals Leuven
Leuven, , Belgium
Academic Medical Center (AMC)
Amsterdam, , Netherlands
Countries
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References
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Van Herpe T, Mesotten D, Wouters PJ, Herbots J, Voets E, Buyens J, De Moor B, Van den Berghe G. LOGIC-insulin algorithm-guided versus nurse-directed blood glucose control during critical illness: the LOGIC-1 single-center, randomized, controlled clinical trial. Diabetes Care. 2013 Feb;36(2):188-94. doi: 10.2337/dc12-0584. Epub 2012 Sep 6.
Van Herpe T, De Brabanter J, Beullens M, De Moor B, Van den Berghe G. Glycemic penalty index for adequately assessing and comparing different blood glucose control algorithms. Crit Care. 2008;12(1):R24. doi: 10.1186/cc6800. Epub 2008 Feb 26.
Van den Berghe G, Schetz M, Vlasselaers D, Hermans G, Wilmer A, Bouillon R, Mesotten D. Clinical review: Intensive insulin therapy in critically ill patients: NICE-SUGAR or Leuven blood glucose target? J Clin Endocrinol Metab. 2009 Sep;94(9):3163-70. doi: 10.1210/jc.2009-0663. Epub 2009 Jun 16.
Dubois J, Van Herpe T, van Hooijdonk RT, Wouters R, Coart D, Wouters P, Van Assche A, Veraghtert G, De Moor B, Wauters J, Wilmer A, Schultz MJ, Van den Berghe G, Mesotten D. Software-guided versus nurse-directed blood glucose control in critically ill patients: the LOGIC-2 multicenter randomized controlled clinical trial. Crit Care. 2017 Aug 14;21(1):212. doi: 10.1186/s13054-017-1799-6.
Other Identifiers
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ML9517
Identifier Type: OTHER
Identifier Source: secondary_id
S55613
Identifier Type: OTHER
Identifier Source: secondary_id
80M0563
Identifier Type: OTHER
Identifier Source: secondary_id
IWT-TBM 100793
Identifier Type: OTHER_GRANT
Identifier Source: secondary_id
LOGIC-Insulin 2.1.1
Identifier Type: -
Identifier Source: org_study_id
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