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Neutrophil Gelatinase Associated Lipocalin (NGAL) in Urine: Can This Prove to be a Biomarker for Acute Kidney Injury in Patients With Sepsis?

NCT ID: NCT02034240

Last Updated: 2015-04-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

21 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-01-31

Study Completion Date

2015-04-30

Brief Summary

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Patients with severe infection and sepsis are in high risk of hypo perfusion and therefore organ affection. Temporary or permanent kidney failure is a common complication in these patients. Today's golden standard for kidney failure detection is creatinine levels rising and / or oliguria. The investigators hypothesize that an even more sensitive biomarker; neutrophil gelatinase associated lipocalin(NGAL) in urine can predict kidney injury before creatinine levels rise. In recent studies NGAL in urine seem to be a sensitive biomarker in these patient to predict kidney injury, but the time factor for sampling optimally is not known. In this pilot study the investigators sample the urine at admission within the first hour of hospitalization to investigate if NGAL can be used as a predictor in an emergency setting.

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Detailed Description

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Conditions

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Severe Sepsis Septic Shock Acute Kidney Injury

Eligibility Criteria

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Inclusion Criteria

* Severe sepsis
* Septic shock
* Patients must not be able to give consent

Exclusion Criteria

* Underaged (18 years )
* known kidney injury
* Fully alert patients that can give consent
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Kolding Sygehus

OTHER

Sponsor Role collaborator

Sygehus Lillebaelt

OTHER

Sponsor Role lead

Responsible Party

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Claes Falkenberg Elvander

Medical Doctor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jannie Bisgaard Stæhr, PhD, M.D

Role: STUDY_CHAIR

Odense University Hospital

Claes Falkenberg Elvander, M.D

Role: STUDY_DIRECTOR

Kolding Sygehus

Srishamanthi Sriskandarajah, M.D

Role: PRINCIPAL_INVESTIGATOR

Kolding Sygehus

Locations

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Faelles Akut Modtagelse, Kolding Sygehus

Kolding, , Denmark

Site Status

Countries

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Denmark

Other Identifiers

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DNVK:1305 385

Identifier Type: -

Identifier Source: org_study_id

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