Role of Neuronal Guidance Proteins as Diagnostic Markers for Acute Kidney Injury (AKI)

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

600 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-08-31

Study Completion Date

2026-07-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Acute kidney failure remains one of the most challenging entities to diagnose in clinical medicine, especially in the field of intensive care. The diagnosis of acute kidney injury is based solely on urine output and serum creatinine, both of which could also be influenced by other factors. A more sensitive and faster diagnostic option would not only be desirable but of utmost clinical importance. Therefore, the investigators aim to identify Neuronal Guidance Proteins (NGPs) as potential biomarkers for the identification and early detection of AKI with this investigation. This investigation aims to identify the possibility of diagnosing acute kidney injury, the subsequent validation of a potential biomarker will then have to take place in a multicenter study approach: Data in preclinical mouse models suggest that SEMA7A as one of the NGPs could be valuable as a biomarker, the study now aims to attempt a preliminary survey in humans and measure various NGPs.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Assessment of AI Prediction Models in Prediction of Acute Kidney Injury in Critical Patients

NCT06857188

Acute Kidney Failure Artificial Intelligence (AI)

NOT_YET_RECRUITING

Incidence of Acute Kidney Injury and Mortality in Critically Ill Patients: Urinary Chloride as a Prognostic Marker

NCT05542927

Acute Kidney Injury

UNKNOWN

Nephroprotective Measures in Critically Ill Patients With Moderate/Severe Acute Kidney Injury

NCT06472999

Acute Kidney Injury

RECRUITING

NGAL and Renal Resistive Index in the Diagnosis and Prognosis of Sepsis-associated AKI

NCT05374759

Sepsis Acute Kidney Injury

COMPLETED

Combining CAF, L-FABP and NGAL as a Potentially Diagnostic Model for Acute Kidney Injury.

NCT04555382

Acute Kidney Injury

UNKNOWN

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Acute Kidney Injury

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Cardiac Surgery

Patients undergoing cardiac surgery

No interventions assigned to this group

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Patients undergoing cardiac surgery
* written consent

Exclusion Criteria

* no written consent possible
* Polytrauma, severe burns
* Immunosuppression
* Pregnancy
* Diagnosis of Hepatitis B, Hepatitis C, and/or HIV
* Sepsis
* Pre-existing kidney damage

Minimum Eligible Age

18 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No