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Regional Cerebral Hemodynamics Related to Global Hemodynamics

NCT ID: NCT01995565

Last Updated: 2013-11-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

64 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-07-31

Brief Summary

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This prospective investigation studies changes in regional cerebral hemodynamics and oxygenation as a function of cardiac output and blood pressure in intensive care patients.

Detailed Description

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Cerebral blood flow velocity (as an index of regional perfusion), dynamic cerebral autoregulation and regional cerebral oxygen saturation should be monitored if disturbances of cerebral perfusion and oxygenation have to be suspected. Noninvasive monitoring techniques are established. When detected early, disturbed perfusion and oxygenation may be treated promptly and permanent damage of brain tissue can be avoided.

In critically ill patients, hemodynamic changes occur due to the disease itself but also as a function of diagnostic and therapeutic procedures. Systemic hemodynamic changes can be monitored using PiCCO® system (pulse contour cardiac output, Pulsion Medical Systems, Munich, Germany) that combines transpulmonal thermodilution and pulse contour analysis. PiCCO® continuously monitors cardiac output (CO), as well as static parameters like global enddiastolic blood volume index (GEDVI), and dynamic parameters as difference in pulse pressure (dPP) and stroke volume variation (SVV), respectively. CC Nexfin® (BMeye, Amsterdam, The Netherlands) is a noninvasive hemodynamic monitor.

This study investigates the effects of changes in cardiac output on cerebral blood flow velocity and regional cerebral oxygen saturation in intensive care patients that underwent major abdominal surgery.

Conditions

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Critically Ill Patients

Study Design

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Study Time Perspective

PROSPECTIVE

Interventions

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PLR

Intervention Type OTHER

Other Intervention Names

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To test fluid responsiveness passive leg raising is performed

Eligibility Criteria

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Inclusion Criteria

* critically ill
* mechanically ventilated
* needing advanced hemodynamic monitoring (PiCCO)

Exclusion Criteria

* \<18years
* \> 80years
* rhythm other than sinus
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Johannes Gutenberg University Mainz

OTHER

Sponsor Role lead

Responsible Party

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Dorothea Closhen

MD

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Johannes Gutenberg University Mainz

Mainz, , Germany

Site Status RECRUITING

Countries

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Germany

Facility Contacts

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Dorothea Closhen, MD

Role: primary

Other Identifiers

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837.437.11(7979)

Identifier Type: OTHER

Identifier Source: secondary_id

CLS_002

Identifier Type: -

Identifier Source: org_study_id