Anti-histamines and Methacholine Challenges.

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

12 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-11-30

Study Completion Date

2014-05-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The asthmatic airway is identified and studied using inhaled agents such as histamine and methacholine. The use of antihistamines prior to the test will inhibit the test result if histamine is used to cause airway constriction. If using methacholine, this may also be true depending on whether old (e.g. benadryl) or new (e.g. desloratadine) antihistamines are used. This study will look at the effect of old and new antihistamines on inhaled methacholine challenge response in individuals with mild asthma.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Methacholine Challenge: Comparison of Doubling and Quadrupling Methacholine Dose Regimes Using the Tidal Volume Method

NCT00890539

Asthma

COMPLETED NA

Change in Airway Responsiveness After Allergen Exposure

NCT01699594

Allergic Asthma

COMPLETED NA

The Effect of Allergen Inhalation on Sputum Myeloid and Plasmacytoid Dendritic Cells in Mild Atopic Asthmatics

NCT00625989

Asthma

COMPLETED EARLY_PHASE1

Duration of Protective Effect From Inhaled Ipratropium Bromide on Methacholine Airway Hyperresponsiveness

NCT00605410

Asthma

COMPLETED PHASE4

Bronchial Hyperreactivity During Histamine Passive Exposure

NCT01937494

Asthma Bronchial Hyperresponsiveness

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Asthma

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

diphenhydramine

50mg dose given as two 25mg capsules

Group Type ACTIVE_COMPARATOR

Diphenhydramine

Intervention Type DRUG

cetirizine

10mg dose given as 1 10mg capsule and 1 placebo capsule

Group Type ACTIVE_COMPARATOR

cetirizine

Intervention Type DRUG

desloratadine

5mg dose given as 1 5mg capsule and 1 placebo capsule

Group Type ACTIVE_COMPARATOR

desloratadine

Intervention Type DRUG

placebo

given as 2 placebo capsules

Group Type PLACEBO_COMPARATOR

placebo

Intervention Type DRUG

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Diphenhydramine

Intervention Type DRUG

cetirizine

Intervention Type DRUG

desloratadine

Intervention Type DRUG

placebo

Intervention Type DRUG

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Baseline forced expiratory volume in 1s (FEV1) of 70% or more of predicted
* Methacholine provocative concentration causing a 20% fall in FEV1 16mg/ml or less
* No respiratory infection or change in allergen exposure for 4 weeks prior to screening and throughout the study
* No significant medical co-morbidities
* allergy