Effects of Allergen Inhalation on Adenosine Receptor Expression in Sputum and Peripheral Blood

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2005-07-31

Study Completion Date

2007-02-28

Brief Summary

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The purpose of this study is to determine whether asthmatics have different adenosine receptor expression profiles than healthy controls. We hypothesize that asthmatics will have increased adenosine receptor expression versus control subjects.

We also want to study the effects of allergen inhalation on adenosine receptor expression in asthmatics. We believe that adenosine receptor expression will be upregulated after allergen inhalation.

Both hypotheses are being tested in sputum and peripheral blood.

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Detailed Description

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Conditions

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Asthma Healthy

Study Design

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Observational Model Type

DEFINED_POPULATION

Study Time Perspective

OTHER

Interventions

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allergen inhalation

Intervention Type BEHAVIORAL

withdrawal of medication

Intervention Type BEHAVIORAL

sputum induction

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Clinical diagnosis of asthma
* Steroid naive or subjects not using their inhaled steroids for the last 4 weeks, short-acting beta-agonist for rescue medication
* FEV1 \> 70% of predicted
* Positive skin prick test for house dust mite, cat or grass pollen
* PC20 methacholine or histamine \< 8 mg/ml

* No airway complaints
* FEV1 \> 90% of predicted
* Negative skin prick test
* PC20 methacholine or histamine \> 8 mg/ml

Exclusion Criteria

* Use of systemic steroids in the previous 6 weeks
* Asthma exacerbations in the previous 6 weeks
* Current or ex-smokers with ≥ 10 pack-years (≥ 2 pipe pack-years), ex smokers who stopped less than 1 year ago

* Use of steroids in the previous 6 weeks
* Current or ex-smokers with ≥ 10 pack-years (≥ 2 pipe pack-years), ex smokers who stopped less than 1 year ago

Minimum Eligible Age

18 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes