Change in Airway Responsiveness After Allergen Exposure
NCT ID: NCT01699594
Last Updated: 2015-04-09
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
11 participants
INTERVENTIONAL
2012-10-31
2014-05-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
NONE
Study Groups
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Mannitol
This arm will assess the allergen induced change in airway responsiveness to mannitol bronchoprovocation.
Mannitol
Indirect bronchoprovocation agent being compared to direct bronchoprovocation agent (methacholine)
Methacholine Chloride
This arm will assess the allergen induced change in airway responsiveness to methacholine bronchoprovocation.
Methacholine Chloride
Direct bronchoprovocation agent being compared to indirect bronchoprovocation agent (mannitol)
Interventions
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Mannitol
Indirect bronchoprovocation agent being compared to direct bronchoprovocation agent (methacholine)
Methacholine Chloride
Direct bronchoprovocation agent being compared to indirect bronchoprovocation agent (mannitol)
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* FEV1 greater than 70% predicted
* methacholine PC20 less than or equal to 16mg/ml
Exclusion Criteria
* diagnosis of any other respiratory or non respiratory disease/disorder that would preclude the individual from participating
* recent thoracic, abdominal or eye surgery
* recent allergen exposure (4 weeks), respiratory infection (6 weeks)
* current immunotherapy
* pregnancy
* history of anaphylaxis
* use of asthma therapies other than short acting beta agonist
18 Years
65 Years
ALL
No
Sponsors
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University of Saskatchewan
OTHER
Responsible Party
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Principal Investigators
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Donald W Cockcroft, MD
Role: PRINCIPAL_INVESTIGATOR
University of Saskatchewan
Locations
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University of Saskatchewan
Saskatoon, Saskatchewan, Canada
Countries
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References
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Amakye DO, Davis BE, Martin AL, Peters GE, Cockcroft DW. Refractoriness to inhaled mannitol 3 hours after allergen challenge. Ann Allergy Asthma Immunol. 2013 Sep;111(3):182-4. doi: 10.1016/j.anai.2013.06.011. Epub 2013 Jul 12.
Other Identifiers
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BioReb #10-227
Identifier Type: OTHER
Identifier Source: secondary_id
IIS-A-524
Identifier Type: -
Identifier Source: org_study_id
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