Tezepelumab and Methacholine Airway Hyperresponsiveness in Participants With Mild Allergic Asthma

NCT ID: NCT05740748

Last Updated: 2023-02-23

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: PHASE2
• Total Enrollment: 34 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2023-04-01
• Study Completion Date: 2024-12-30

Brief Summary

Asthma is a condition where small inhaled particles can cause inflammation in the lung leading to constriction of airways and wheeze. Mast cells are immune cells in airways that can release chemical causing constriction of the airways and wheeze. Tezepelumab is an injectable medication that improves asthma by stopping inflammation, but the effect on mast cells is not known. Tezepelumab was approved in Canada July 2022 for treatment of severe asthma. Tezepelumab is not approved for treatment of mild asthma by any health authority, except for use in research studies like this. This study will examine the effect of tezepelumab on mast cells and airway constriction to understand the mechanisms of asthma, and which patients will benefit most from drugs like tezepelumab.

Detailed Description

The proposed study will address whether tezepelumab has the unique ability to improve AHR in participants with mild allergic asthma.

This is a phase 2 multi-centre randomized double-blind placebo-controlled parallel-group study to examine the effects of 24 weeks tezepelumab 210 mg sc q4wks on methacholine airway hyperresponsiveness in participants with mild allergic asthma, stratified for sex and sensitivity to seasonal allergens.

There are 9 study visits over a period of 27 weeks (Figure 1). Study procedures performed at Weeks -1, 8, 16 and 24 will be divided across 2 visits at least 48 hours apart for measurement of AHR to methacholine first, and mannitol at least 48 hours later.

The screening period at Week -1 will determine eligibility. At Week -1, eligible allergic mild asthmatic participants will be randomized 1:1 to placebo or tezepelumab 210 mg subcutaneous administered monthly for a total of 24 weeks. AHR will be measured by methacholine and mannitol challenges at baseline (Week -1) performed at least 48 hours apart. Changes in AHR response will be measured by repeat methacholine and mannitol challenges at Weeks 8, 16 and 24.

Conditions

Asthma, Allergic

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: TRIPLE

Study Groups

Tezepelumab

tezepelumab 210 mg sc q4wks 20 weeks treatment

Group Type: EXPERIMENTAL

Tezepelumab

Intervention Type: DRUG

tezepelumab 210 mg sc q4wks for 20 weeks

Placebo

placebo sc q4wks 20 weeks treatment

Group Type: PLACEBO_COMPARATOR

Placebo

Intervention Type: DRUG

placebo sc q4wks for 20 weeks

Interventions

Tezepelumab

tezepelumab 210 mg sc q4wks for 20 weeks

Intervention Type: DRUG

Placebo

placebo sc q4wks for 20 weeks

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

1. Provision of informed consent prior to any study specific procedures

2. Male and female 18 through 65 years of age

3. Positive skin-prick test to a common aeroallergen

4. Methacholine PD20 ≤ 200mcg

5. Mannitol DRR ≤ 42.3mg/FEV1 %f all (equivalent to PD15 ≤ 635mg)

6. Baseline FEV1 ≥ 70% of the predicted value

7. Negative pregnancy test (urine) for female participants of childbearing potential.

Exclusion Criteria

1. Current or former smoker with >10-pack-year history

2. Current or previous history of lung disease other than mild stable allergic asthma

3. Significant systemic disease, including history of current malignancy or autoimmune disease

4. Involvement in the planning and/or conduct of the study (applies to both Investigator staff and/or staff at the study site)

5. Previous randomisation in the present study. Re-screening (Week -1) for FEV1 and AHR is permitted once for each test.

6. Participation in another clinical study with an investigational product during the last 30 days or 5 half-lives of the drug (whichever is longer)

7. Use of any medications for treatment of asthma other than prophylactic short-acting β2-agonists, or use of short-acting β2-agonists for relief of symptoms less than once weekly.

8. Participants with known hypersensitivity to tezepelumab or any of the excipients of the product.

9. Positive hepatitis C antibody, hepatitis B virus surface antigen or hepatitis B virus core antibody, at screening

10. Known to have tested positive for human immunodeficiency virus

11. Known history of drug or alcohol abuse within 1 year of screening

12. For women only - currently pregnant (confirmed with positive pregnancy test) or breast feeding.

13. Unwillingness or inability to comply with the study protocol for any other reason.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

University of Saskatchewan

OTHER

Sponsor Role: collaborator

McMaster University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Gail Gauvreau, PhD

Role: PRINCIPAL_INVESTIGATOR

McMaster University

Locations

McMaster University

Hamilton, Ontario, Canada

University of Saskatchewan

Saskatoon, Saskatchewan, Canada

Countries

Canada

Central Contacts

Gail M Gauvreau, PhD

Role: CONTACT

gauvreau@mcmaster.ca

9055259140 ext. 22791

Paul M O'Byrne, MB

Role: CONTACT

obyrnep@mcmaster.ca

9055259140 ext. 22100

Facility Contacts

Gail M Gauvreau, PhD

Role: primary

gauvreau@mcmaster.ca

9055259140 ext. 22791

Paul M O'Byrne, MB

Role: backup

obyrne@mcmaster.ca

9055259140 ext. 22100

Beth Davis, PhD

Role: primary

beth.davis@usask.ca

(306) 844-1444

Donald Cockcroft, MD

Role: backup

don.cockcroft@usask.ca

(306) 844-1444

Other Identifiers

ESR-22-21828

Identifier Type: -

Identifier Source: org_study_id