Oral Curcumin Supplementation in Middle-Aged and Older Adults Improves Vascular Function

NCT ID: NCT01968564

Last Updated: 2017-03-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

118 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-06-30

Study Completion Date

2017-06-30

Brief Summary

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The proposed study will assess the ability of curcumin, the active ingredient in the Indian spice tumeric, to improve the function of arteries with age. Overall, the proposed research project has the long-term potential to influence clinical practice guidelines by establishing a novel, easy to deliver, cost-effective therapy for treating age-associated arterial dysfunction and reducing the risk of cardiovascular disease with age.

Detailed Description

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Conditions

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Vascular Aging

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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High-dose curcumin pill

Group Type EXPERIMENTAL

High-dose curcumin pill

Intervention Type DRUG

2000mg curcumin pill/day

Low-dose curcumin pill

Group Type EXPERIMENTAL

Low-dose curcumin pill

Intervention Type DRUG

500mg curcumin pill/day

Placebo pill

Group Type PLACEBO_COMPARATOR

Placebo pill

Intervention Type DRUG

sugar and other inert substances

Interventions

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Placebo pill

sugar and other inert substances

Intervention Type DRUG

High-dose curcumin pill

2000mg curcumin pill/day

Intervention Type DRUG

Low-dose curcumin pill

500mg curcumin pill/day

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* women must be postmenopausal
* body mass index (BMI) \<40 kg/m2
* weight stable in the prior 3 months
* absence of clinical disease as determined by medical history, physical examination, blood and urine chemistries, ankle-brachial index, and a graded exercise stress test with monitoring of blood pressure and 12-lead ECG
Minimum Eligible Age

45 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Colorado, Boulder

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jessica Santos-Parker, MS

Role: STUDY_DIRECTOR

University of Colorado, Boulder

Douglas Seals, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Colorado, Boulder

Locations

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University of Colorado Boulder, Clinical Translational Research Center

Boulder, Colorado, United States

Site Status

Countries

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United States

Related Links

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http://www.colorado.edu/intphys/research/cardiovascular.html

Link Text: Description of our Research and Laboratory

Other Identifiers

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B6398

Identifier Type: -

Identifier Source: org_study_id

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