Color Doppler Analysıs Of Uterin And Intraovarian Blood Flow Before And After Treatment Wıth Cabergoline In Hyperprolactinemic Patients

NCT ID: NCT01957839

Last Updated: 2013-10-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

48 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-03-31

Study Completion Date

2011-09-30

Brief Summary

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the investigators examined the hypothesis that hyperprolactinemia may alter uterin, endometrial and intraovarian blood flow and may contribute to increased infertility by another way.

Detailed Description

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Conditions

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Adverse Reaction to Other Drugs and Medicines

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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pretreatment group

doppler evaluation at pretreatment period

Group Type NO_INTERVENTION

No interventions assigned to this group

posttreatment group

doppler evaluatıon in normoprolactinemia women who given cabergoline treatment

Group Type EXPERIMENTAL

cabergoline treatment

Intervention Type DRUG

cabergoline treatment for hyperprolactinemia group

Interventions

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cabergoline treatment

cabergoline treatment for hyperprolactinemia group

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Women who had blood prolactin level higher than 25ng/dl

Exclusion Criteria

* Pregnancy
* Use of drugs effecting vasculature such as hormonal therapy, oral contraceptives, antihypertensives
* Diseases like pelvic inflammatory disease and systemic hypertension
* Women with clinically overt or treated cardiovascular disease
* Concurrent illness other than hyperprolactinemia
Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Istanbul Bakirkoy Maternity and Children Diseases Hospital

OTHER_GOV

Sponsor Role lead

Responsible Party

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Osman Aşıcıoğlu

sisli etfal teaching hospital department gynecology and obstetric

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Osman Temizkan, M.D.

Role: PRINCIPAL_INVESTIGATOR

SİSLİ ETFAL TEACHİNG HOSPİTAL

Locations

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Sisli Etfal Teaching Hosital

Şişli, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

References

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Ono M, Miki N, Amano K, Kawamata T, Seki T, Makino R, Takano K, Izumi S, Okada Y, Hori T. Individualized high-dose cabergoline therapy for hyperprolactinemic infertility in women with micro- and macroprolactinomas. J Clin Endocrinol Metab. 2010 Jun;95(6):2672-9. doi: 10.1210/jc.2009-2605. Epub 2010 Mar 31.

Reference Type BACKGROUND
PMID: 20357175 (View on PubMed)

Temizkan O, Temizkan S, Asicioglu O, Aydin K, Kucur S. Color Doppler analysis of uterine, spiral, and intraovarian artery blood flow before and after treatment with cabergoline in hyperprolactinemic patients. Gynecol Endocrinol. 2015 Jan;31(1):75-8. doi: 10.3109/09513590.2014.958989. Epub 2014 Sep 15.

Reference Type DERIVED
PMID: 25222841 (View on PubMed)

Other Identifiers

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OA8

Identifier Type: OTHER

Identifier Source: secondary_id

Aşıcıoğlu-08

Identifier Type: -

Identifier Source: org_study_id