Risk-adapted Screening in First-degree Relatives of Patients With Colorectal Cancer

NCT ID: NCT01903395

Last Updated: 2016-10-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

313 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-03-31

Study Completion Date

2015-12-31

Brief Summary

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BACKGROUND: First-degree relatives of patients with colorectal cancer are at increased risk for colorectal cancer as well. Nevertheless, participation in the German national screening program stagnates at 2-3 percent per year even in this high-risk population.

AIM: The study is aimed to increase the portion of the first-degree relatives on 50% which take up a preventive colonoscopy.

METHODS: Cluster-randomized controlled multi-center trial. Study sites (clusters) are mainly certified cancer centers and office-based gastroenterologists from all over Germany. Index-patients with colorectal cancer of different stages are asked to hand over the study material to their relatives, consisting of an invitation to a nurse-led counseling on preventive colonoscopy and an one-to-one appointment with a clinical expert of one of the study sites next.

Detailed Description

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Conditions

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Colorectal Neoplasms

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Participants

Study Groups

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Nurse-led counselling

First-degree relatives of patients undergoing active treatment for colorectal cancer are offered a nurse-led counselling by telephone regarding emotional and cognitive barriers to screening utilization.

Group Type EXPERIMENTAL

Nurse-led counselling

Intervention Type BEHAVIORAL

Nurse-led telephone counselling to double the utilization of preventive colonoscopy

Usual Care

Usual print media, offered standardly by the recruiting centres.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Nurse-led counselling

Nurse-led telephone counselling to double the utilization of preventive colonoscopy

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* aged 18 and over
* being first-degree relatives of patients with diagnosed colorectal cancer
* able to understand German

Exclusion Criteria

* Familial Adenomatous Polyposis
* utilization of diagnostic colonoscopy within the past 5 years
* being ever treated for colorectal cancer
* actual inflammatory bowl disease
* comorbidities associated with reduced further life expectancy (ECOG performance status \>3
Minimum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Martin-Luther-Universität Halle-Wittenberg

OTHER

Sponsor Role lead

Responsible Party

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Alexander Bauer

PhD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Alexander Bauer, PhD

Role: PRINCIPAL_INVESTIGATOR

Martin-Luther-University Halle-Wittenberg, Medical Faculty, Institute for Health and Nursing Science

Locations

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Kliniken Landkreis Sigmaringen GmbH

Sigmaringen, Baden-Wurttemberg, Germany

Site Status

Klinikum Ludwigsburg

Ludwigsburg, Baden-Würtemberg, Germany

Site Status

Diakoniekrankenhaus Mannheim

Mannheim, Baden-Würtemberg, Germany

Site Status

Klinikum Stuttgart Krankenhaus Bad Cannstatt

Stuttgart, Baden-Würtemberg, Germany

Site Status

Universitätsklinikum Ulm

Ulm, Baden-Würtemberg, Germany

Site Status

Klinikum Aschaffenburg

Aschaffenburg, Bavaria, Germany

Site Status

Universitätsklinikum Erlangen

Erlangen, Bavaria, Germany

Site Status

Stiftung Juliusspital Würzburg

Würzburg, Bavaria, Germany

Site Status

Klinikum Barnim

Eberswalde, Brandenburg, Germany

Site Status

Klinikum Hanau

Hanau, Hesse, Germany

Site Status

Universitätsklinikum Gießen und Marburg

Marburg, Hesse, Germany

Site Status

Städtisches Klinikum Braunschweig

Braunschweig, Lower Saxony, Germany

Site Status

Allgemeines Krankenhaus Celle

Celle, Lower Saxony, Germany

Site Status

Städtisches Klinikum Lüneburg

Lüneburg, Lower Saxony, Germany

Site Status

Klinikum Osnabrück GmbH

Osnabrück, Lower Saxony, Germany

Site Status

HELIOS Kliniken Schwerin

Schwerin, Mecklenburg-Vorpommern, Germany

Site Status

Universitätsklinikum Knappschaftskrankenhaus Ruhr Universität Bochum

Bochum, Nordrhein-Wetsfalen, Germany

Site Status

Krankenhaus Köln-Holweide

Cologne, North Rhine-Westphalia, Germany

Site Status

Klinik Evang. Krankenhaus Kalk

Cologne, North Rhine-Westphalia, Germany

Site Status

Johanniter-Krankenhaus Rheinhausen

Duisburg, North Rhine-Westphalia, Germany

Site Status

Sankt Elisabeth Hospital Gütersloh

Gütersloh, North Rhine-Westphalia, Germany

Site Status

Klinikum Lüdenscheid

Lüdenscheid, North Rhine-Westphalia, Germany

Site Status

Krankenhaus St. Marienwörth

Bad Kreuznach, Rhineland-Palatinate, Germany

Site Status

Diakonissen-Stiftungs-Krankenhaus Speyer

Speyer, Rhineland-Palatinate, Germany

Site Status

Gastroenterologische Schwerpunktpraxis Völklingen

Völklingen, Saarland, Germany

Site Status

Evangelisches Diakonissenkrankenhaus Leipzig gGmbH

Leipzig, Saxony, Germany

Site Status

Diakonissenkrankenhaus Dessau gemeinnützige GmbH

Dessau, Saxony-Anhalt, Germany

Site Status

Klinikum Magdeburg gemeinnützige GmbH

Magdeburg, Saxony-Anhalt, Germany

Site Status

HELIOS Klinik Sangerhausen

Sangerhausen, Saxony-Anhalt, Germany

Site Status

Evangelisches Krankenhaus Paul Gerhardt Stift

Wittenberg, Saxony-Anhalt, Germany

Site Status

Praxis für Innere Medizin Dr. med. Regine Lange

Wittenberg, Saxony-Anhalt, Germany

Site Status

Westküstenklinikum Heide

Heide, Schleswig-Holstein, Germany

Site Status

Universitätsklinikum Jena

Jena, Thuringia, Germany

Site Status

Countries

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Germany

Other Identifiers

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NKP332-032

Identifier Type: -

Identifier Source: org_study_id

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