Colorectal Cancer Screening Intervention for Family Members of Colorectal Cancer Patients

NCT ID: NCT00582829

Last Updated: 2008-11-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

213 participants

Study Classification

OBSERVATIONAL

Study Start Date

2003-06-30

Study Completion Date

2008-05-31

Brief Summary

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This proposed study will use previous study results to guide the development and evaluation of interventions to improve CRC screening acceptance. The proposed study will evaluate the impact of three interventions to promote CRC screening among siblings in this increased-risk group, who are not currently compliant with CRC screening guidelines: 1) a generic print intervention; 2) a tailored print intervention, and; 3) a tailored print plus tailored telephone counseling intervention.

Detailed Description

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First-degree relatives of individuals with CRC are at increased-risk of developing colorectal cancer (CRC). For these increased-risk individuals current guidelines recommend initiating CRC screening a decade earlier than for those at average-risk for CRC; thus, starting at age 40, or 10 years younger than the age at which the affected relative was diagnosed with CRC. In our prior study of 504 at-risk siblings of patients with a history of CRC, diagnosed at age less than 56, we found that approximately 44% of these siblings were not compliant with CRC screening guidelines. Guided by the Transtheoretical, Health Belief and Dual Process models, our prior study identified key attitudinal and non-attitudinal predictors of screening behaviors and intentions.

This proposed study will use these results to guide the development and evaluation of interventions to improve CRC screening acceptance. The proposed study will evaluate the impact of three interventions to promote CRC screening among siblings in this increased-risk group, who are not currently compliant with CRC screening guidelines: 1) a generic print intervention; 2) a tailored print intervention, and; 3) a tailored print plus tailored telephone counseling intervention.

Siblings in the generic print condition will receive a pamphlet about colorectal cancer screening published by the Center for Disease Control. Siblings in the tailored print and telephone counseling conditions will receive messages tailored specifically to their responses on targeted attitudinal and non-attitudinal measures. Five hundred twenty four siblings meeting eligibility criteria will be randomly assigned to one of the three conditions after a baseline interview assessing CRC screening behaviors and attitudes, and it is anticipated that 427 siblings will complete the study. For siblings in the tailored conditions, baseline information will be utilized to design the tailored messages. After receiving the intervention information, participants will be interviewed again six months later regarding CRC screening behaviors and attitudes to assess the impact of the intervention.

Conditions

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Colorectal Cancer Screening Intervention

Keywords

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Colorectal Cancer Screening Intervention Family

Study Groups

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1

Generic Print Intervention: The generic print intervention will consist of the pamphlet, "Colorectal Cancer Screening Saves Lives" published by the Center for Disease Control that will be mailed to the participant.

Generic Print Intervention

Intervention Type OTHER

Generic Print Intervention: The generic print intervention will consist of the pamphlet, "Colorectal Cancer Screening Saves Lives" published by the Center for Disease Control that will be mailed to the participant.

2

Tailored Print Intervention: The tailored print intervention will consist of a cover letter detailing the participant's stage of readiness along with a color pamphlet with information personally tailored for the individual participant.

Tailored Print Intervention

Intervention Type OTHER

Tailored Print Intervention: The tailored print intervention will consist of a cover letter detailing the participant's stage of readiness along with a color pamphlet with information personally tailored for the individual participant.

3

Tailored print plus tailored phone intervention: The tailored print plus tailored telephone intervention will consist of a phone counseling session and the tailored print information described above. The tailored print material will serve as a guide during the telephone counseling contact and a reinforcement of the information.

Tailored print plus tailored phone intervention

Intervention Type OTHER

Tailored print plus tailored phone intervention: The tailored print plus tailored telephone intervention will consist of a phone counseling session and the tailored print information described above. The tailored print material will serve as a guide during the telephone counseling contact and a reinforcement of the information.

Interventions

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Generic Print Intervention

Generic Print Intervention: The generic print intervention will consist of the pamphlet, "Colorectal Cancer Screening Saves Lives" published by the Center for Disease Control that will be mailed to the participant.

Intervention Type OTHER

Tailored Print Intervention

Tailored Print Intervention: The tailored print intervention will consist of a cover letter detailing the participant's stage of readiness along with a color pamphlet with information personally tailored for the individual participant.

Intervention Type OTHER

Tailored print plus tailored phone intervention

Tailored print plus tailored phone intervention: The tailored print plus tailored telephone intervention will consist of a phone counseling session and the tailored print information described above. The tailored print material will serve as a guide during the telephone counseling contact and a reinforcement of the information.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* How old is the participant? (≥ 18 years)
* Is the participant either:
* currently age 40 or above (YES) OR
* within 10 years of the age at which the patient/proband was initially diagnosed with CRC (whichever is the younger age) (YES)
* Is the participant a full or half biological sibling of the patient/proband? (YES)

Exclusion Criteria

* Is the participant currently not compliant with standard CRC screening guidelines? (NO)
* Is the participant English speaking? (YES)
* Does the participant have a primary language other than English? (NO)
* Does the participant have a history of Inflammatory Bowel Disease? (NO)
* Does the participant have a history of colorectal cancer of colorectal polyp? (NO)
* Does the participant have a history of hereditary colorectal cancer syndrome? (Familial Adenomatous Polyposis or Hereditary Nonpolyposis Colorectal Cancer) (NO)
Minimum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Cancer Institute (NCI)

NIH

Sponsor Role collaborator

Fox Chase Cancer Center

OTHER

Sponsor Role collaborator

Icahn School of Medicine at Mount Sinai

OTHER

Sponsor Role collaborator

Lombardi Comprehensive Cancer Center

OTHER

Sponsor Role collaborator

Micromass Communications, Cary, NC

UNKNOWN

Sponsor Role collaborator

University of Pennsylvania

OTHER

Sponsor Role collaborator

Christiana Care Health Services

OTHER

Sponsor Role collaborator

Pinnacle Health Regional Cancer Center, Harrisburg, PA

UNKNOWN

Sponsor Role collaborator

Temple University

OTHER

Sponsor Role collaborator

St. Mary Regional Cancer Center, Langhorne, PA

UNKNOWN

Sponsor Role collaborator

South Jersey Regional Cancer Center, Bridgton, New Jersey

UNKNOWN

Sponsor Role collaborator

Hunterdon Cancer Center

UNKNOWN

Sponsor Role collaborator

Northeast Regional Cancer Institute

OTHER

Sponsor Role collaborator

Virtua Memorial Hospital and Virtua West

UNKNOWN

Sponsor Role collaborator

Jersey Hospital

UNKNOWN

Sponsor Role collaborator

Rutgers Cancer Institute of New Jersey

OTHER

Sponsor Role collaborator

Massachusetts General Hospital

OTHER

Sponsor Role collaborator

Main Line Health

OTHER

Sponsor Role collaborator

Roswell Park Cancer Institute

OTHER

Sponsor Role collaborator

HematologyOncology

UNKNOWN

Sponsor Role collaborator

Associates of Central New York

UNKNOWN

Sponsor Role collaborator

Augusta University

OTHER

Sponsor Role collaborator

Memorial Sloan Kettering Cancer Center

OTHER

Sponsor Role lead

Responsible Party

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Memorial Sloan Kettering Cancer Center

Principal Investigators

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Arnold Markowitz, MD

Role: PRINCIPAL_INVESTIGATOR

Memorial Sloan Kettering Cancer Center

Locations

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Memorial Sloan Kettering Cancer Center

New York, New York, United States

Site Status

Countries

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United States

Other Identifiers

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03-043

Identifier Type: -

Identifier Source: org_study_id