Altitude, Exercise and Glucose Metabolism in Pre-diabetic Men

NCT ID: NCT01890876

Last Updated: 2019-01-22

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 32 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2013-06-30
• Study Completion Date: 2015-12-31

Brief Summary

Concentric (CE) and eccentric (EE) exercises may differently affect glucose metabolism which may be additionally modified when exercises are performed in hypoxia, e.g. at moderate (1500 - 2500 m) or high (2500 - 3500 m) altitudes. However, data on the effects of glucose metabolism due to CE and EE in hypoxia are scarce but would be of utmost importance considering the increasing number of persons suffering from impaired glucose tolerance or diabetes and the unique opportunities provided by the mountainous regions of the Alps to perform CE (e.g. uphill hiking) and EE (downhill hiking, downhill skiing) at altitude between 1500 - 3500 m. Metabolic responses to exercise may be largely mediated by interleukin 6 (IL-6), which is predominantly derived from the contracting limbs and may support the maintenance of metabolic homeostasis during exercise. In addition, IL-6 is elevated with acute and chronic altitude exposure at least partly mediated via adrenergic stimulation. Thus, the type of exercise as well as hypoxia may contribute to IL-6 elevations and differences in serum IL-6 concentrations might help to explain distinctions between responses of glucose metabolism to CE and EE at low and moderate to high altitude.

32 male subjects suffering from pre-diabetes will be randomly assigned to a downhill (EE) or uphill (CE) walking group performing 9 sessions at low altitude (860 - 1360 m) and 9 sessions at moderate to high altitude (2000 - 2500 m). Between normoxic and hypoxic condition will be a break of approximately 12 month. Measurements of glucose metabolism, IL-6 plasma concentration will be performed pre, mid (day 5) and post intervention. Moreover anthropometric, strength and exercise capacity characteristics will be performed pre and post intervention.

We hypothesize that EE in hypoxia is more effective in the modulation of glycemic control in pre-diabetic men than CE in hypoxia as well as EE and CE in normoxia. It is suggested that effects on glucose metabolism are associated with changes in plasma IL-6 concentrations. EE in hypoxia is expected to result in a more persistent rise of plasma IL-6 concentration than CE in hypoxia and in normoxia and to a more pronounced rise in plasma IL-6 than EE in normoxia.

Detailed Description

Not desired.

Conditions

Diabetes

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: PREVENTION
• Blinding Strategy: NONE

Study Groups

Low altitude

Walking uphill Walking downhill

Group Type: ACTIVE_COMPARATOR

Walking uphill

Intervention Type: OTHER

ascending about 500 m

Walking downhill

Intervention Type: OTHER

descending about 500 m

High altitude

Walking uphill Walking downhill

Group Type: ACTIVE_COMPARATOR

Walking uphill

Intervention Type: OTHER

ascending about 500 m

Walking downhill

Intervention Type: OTHER

descending about 500 m

Interventions

Walking uphill

ascending about 500 m

Intervention Type: OTHER

Walking downhill

descending about 500 m

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Pre-diabetes
• male
• age 50-65 years

Exclusion Criteria

• smoking
• BMI > 30 kg/m2
• diseases not compatible with intervention

• Minimum Eligible Age: 50 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: No

Sponsors

Medical University Innsbruck

OTHER

Sponsor Role: collaborator

Universitaet Innsbruck

OTHER

Sponsor Role: lead

Responsible Party

Martin Burtscher

Univ.-Prof. Mag. DDr. Martin Burtscher

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Martin Burtscher, Professor

Role: PRINCIPAL_INVESTIGATOR

department of sport science, medical section, university innsbruck

Locations

Department of Sport Science, Medical Section, University of Innsbruck

Innsbruck, , Austria

Countries

Austria

References

Drexel H, Saely CH, Langer P, Loruenser G, Marte T, Risch L, Hoefle G, Aczel S. Metabolic and anti-inflammatory benefits of eccentric endurance exercise - a pilot study. Eur J Clin Invest. 2008 Apr;38(4):218-26. doi: 10.1111/j.1365-2362.2008.01937.x.

Reference Type: BACKGROUND

PMID: 18339002 (View on PubMed)

Duennwald T, Gatterer H, Groop PH, Burtscher M, Bernardi L. Effects of a single bout of interval hypoxia on cardiorespiratory control and blood glucose in patients with type 2 diabetes. Diabetes Care. 2013 Aug;36(8):2183-9. doi: 10.2337/dc12-2113. Epub 2013 Mar 27.

Reference Type: BACKGROUND

PMID: 23536585 (View on PubMed)

Burtscher M, Gatterer H, Kunczicky H, Brandstatter E, Ulmer H. Supervised exercise in patients with impaired fasting glucose: impact on exercise capacity. Clin J Sport Med. 2009 Sep;19(5):394-8. doi: 10.1097/JSM.0b013e3181b8b6dc.

Reference Type: BACKGROUND

PMID: 19741312 (View on PubMed)

Philippe M, Junker G, Gatterer H, Melmer A, Burtscher M. Acute effects of concentric and eccentric exercise matched for energy expenditure on glucose metabolism in healthy females: a randomized crossover trial. Springerplus. 2016 Aug 30;5(1):1455. doi: 10.1186/s40064-016-3062-z. eCollection 2016.

Reference Type: DERIVED

PMID: 27652031 (View on PubMed)

Other Identifiers

AN5029

Identifier Type: -

Identifier Source: org_study_id