Identification of Optimal Stimulation Site for Cervical Dystonia Symptoms: An Exploratory Study
NCT ID: NCT01859247
Last Updated: 2016-07-28
Study Results
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View full resultsBasic Information
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COMPLETED
NA
8 participants
INTERVENTIONAL
2013-03-31
2014-06-30
Brief Summary
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Detailed Description
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We will test the hypothesis that rTMS of a distinct premotor site will provide more effective treatment of CD than non-specific activation of the entire premotor region. This will be done by performing a randomized, observer-blinded exploratory pilot study to determine the optimal site of rTMS over various sites of the premotor and motor cortex to improve the symptoms of cervical dystonia. Completion of this aim should lead to development of targeted TMS therapy for CD.
Conditions
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
DOUBLE
Study Groups
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Dorsal Premotor rTMS
0.2 Hz rTMS for 15 minutes
rTMS
Primary motor cortex rTMS
0.2 Hz rTMS for 15 minutes
rTMS
Supplemental Motor Area rTMS
0.2 Hz rTMS for 15 minutes
rTMS
Anterior Cingulate rTMS
0.2 Hz rTMS for 15 minutes
rTMS
Sham rTMS
0.2 Hz rTMS for 15 minutes
rTMS
Interventions
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rTMS
Eligibility Criteria
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Inclusion Criteria
* Age 18 years or older
* Normal findings in the medical history, physical and neurological examination, except for dystonia
* Last treatment with botulinum toxin more than two months ago
Exclusion Criteria
* Pregnancy- a pregnancy test will be performed for women of childbearing potential
* History of any other neurological disorders or conditions requiring the use of anti-depressants that are known to increase seizure threshold, neuroleptic medication, anticholinergic drugs and muscle relaxants
* History of neuroleptic medications/ prior use of neuroleptics
18 Years
100 Years
ALL
No
Sponsors
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Dystonia Coalition
OTHER
National Institutes of Health (NIH)
NIH
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
University Health Network, Toronto
OTHER
University of New Mexico
OTHER
Responsible Party
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Sarah Pirio Richardson
MD
Principal Investigators
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Sarah Pirio Richardson, MD
Role: PRINCIPAL_INVESTIGATOR
University of New Mexico
H.A. Jinnah, MD
Role: STUDY_DIRECTOR
Emory University
Locations
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University of New Mexico
Albuquerque, New Mexico, United States
Countries
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References
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Beck S, Houdayer E, Richardson SP, Hallett M. The role of inhibition from the left dorsal premotor cortex in right-sided focal hand dystonia. Brain Stimul. 2009 Oct;2(4):208-14. doi: 10.1016/j.brs.2009.03.004. Epub 2009 May 3.
Breakefield XO, Blood AJ, Li Y, Hallett M, Hanson PI, Standaert DG. The pathophysiological basis of dystonias. Nat Rev Neurosci. 2008 Mar;9(3):222-34. doi: 10.1038/nrn2337.
Lefaucheur JP, Fenelon G, Menard-Lefaucheur I, Wendling S, Nguyen JP. Low-frequency repetitive TMS of premotor cortex can reduce painful axial spasms in generalized secondary dystonia: a pilot study of three patients. Neurophysiol Clin. 2004 Oct;34(3-4):141-5. doi: 10.1016/j.neucli.2004.07.003.
Murase N, Rothwell JC, Kaji R, Urushihara R, Nakamura K, Murayama N, Igasaki T, Sakata-Igasaki M, Mima T, Ikeda A, Shibasaki H. Subthreshold low-frequency repetitive transcranial magnetic stimulation over the premotor cortex modulates writer's cramp. Brain. 2005 Jan;128(Pt 1):104-15. doi: 10.1093/brain/awh315. Epub 2004 Oct 13.
Pirio Richardson S, Tinaz S, Chen R. Repetitive transcranial magnetic stimulation in cervical dystonia: effect of site and repetition in a randomized pilot trial. PLoS One. 2015 Apr 29;10(4):e0124937. doi: 10.1371/journal.pone.0124937. eCollection 2015.
Other Identifiers
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UNM 657
Identifier Type: -
Identifier Source: org_study_id
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