Neuromuscular Mechanisms Underlying Poor Recovery From Whiplash Injuries

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

97 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-07-31

Study Completion Date

2020-05-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This study is investigating whether changes in the shape and size of bodily muscles and spinal cord anatomy can influence recovery rates following a motor vehicle collision (MVC). The objective is to demonstrate that the presence of muscle and spinal cord degeneration and associated muscle weakness is the consequence of a mild MVC-related injury involving the cervical spinal cord.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Assessment of the Alignment of the Atlas and Surrounding Tissues in Chronic Whiplash Associated Disorder

NCT06413667

Chronic Whiplash Associated Disorder

RECRUITING

Pathophysiological Mechanism Behind Prolonged Whiplash Associated Disorders

NCT03664934

Whiplash Injuries

COMPLETED NA

Evaluation of a Neck Strengthening Program to Reduce the Risk of Sport-related Concussion

NCT02455037

COMPLETED NA

Effectiveness of a Home-based Cervical Motor Control Exercise Programme Versus Conventional Manual Therapy in Patients With Post-whiplash Neck Pain.

NCT07324811

Cervical Disease

COMPLETED NA

Is Chronic Whiplash-associated Pain of Neurogenic Origin?

NCT02692937

Whiplash Injuries

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Whiplash is a condition that consists of patients that display varying degrees of pain and disability. Most patients should expect full-recovery within the first 2-3 months post injury. At the other end of the spectrum is a group of patients (\~ 25%) who continue to have moderate-severe pain-related disability in the long-term. Reasons for this transition to chronicity are largely unknown. The situation would benefit if there were radiological findings of the disorder. However, clear and consistent findings of injured tissues on standard radiological exams remain elusive.

As part of this study, the investigators will innovatively investigate measures to 1) quantify the temporal development of widespread muscle degeneration, 2) identify quantifiable markers of altered cervical spinal cord physiology, 3) quantify reductions in central activation and fatigue 4) evaluate potential genetic variants that may be associated with chronic pain after a MVC and 5) determine the mediational influence of psychosocial factors on recovery rates following whiplash injury, as a potential mechanism underlying the transition to chronic pain.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Whiplash Associated Disorders WAD Whiplash

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Procedures

RNA/DNA blood sample will be collected. Participant will complete questionnaires, MRI and strength and reflex testing.

Group Type EXPERIMENTAL

Pedometer

Intervention Type DEVICE

MRI

Intervention Type DEVICE

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Pedometer

Intervention Type DEVICE

MRI

Intervention Type DEVICE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Males and Females (18 - 65 years of age)
* Individuals less than one week post MVA with a primary complaint of neck pain.
* Able to give written informed consent and complete interviews in English

Exclusion Criteria

* Individuals with a spinal fracture from the MVA, or spinal surgeries
* History of one or more MVAs or previous diagnosis of cervical or lumbar radiculopathy
* History of neurological disorders (e.g. Multiple Sclerosis, previous stroke, myelopathy), inflammatory diseases (e.g. Hepatitis, Systemic Lupus Erythematosus, Rheumatoid Arthritis or Osteoarthritis, Alzheimers, Ankylosing Spondylitis, Crohn's disease, Fibromyalgia) or metabolic disorders (e.g. Diabetes, hyper- and hypo-thyroidism)
* Standard contraindications to MRI: claustrophobia, metallic implants, pacemaker and pregnancy.

Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No