Research of Revascularization in Immature Teeth With Periapical Periodontitis

NCT ID: NCT01799187

Last Updated: 2014-07-22

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 190 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2012-07-31
• Study Completion Date: 2021-07-31

Brief Summary

Revascularization is an alternative new treatment of immature permanent teeth with necrotic pulp nowadays while apexification is the traditional therapy. The investigators suppose that revascularization is superior to apexification at developing the root of immature permanent teeth and reducing the risk of root fracture,and the research is designed.

Detailed Description

The investigators design to collect a group of patients presenting immature permanent teeth with periapical periodontitis in certain criterion. The investigators will divide the patients into two groups randomly. One group will get treated with revascularization while the other with apexification. The investigators want to evaluate the short-term and long-term effects of the two groups to get a conclusion of the clinical value of revascularization.

Conditions

Periapical Periodontitis

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: SINGLE

Study Groups

revascularization

revascularization is is an alternative new treatment of immature permanent teeth with necrotic pulp. The use of triple antibiotic paste is followed by Induction of bleeding from the apical root during this intervention.

Group Type: EXPERIMENTAL

revascularization

Intervention Type: PROCEDURE

revascularization include 3 steps: root disinfected,induction of bleeding and revascularization include 3 steps: root disinfected,induction of bleeding and sealing

apexification

apexification is a traditional therapy of immature permanent teeth with necrotic pulp.calcium hydroxide is served as medication to induce the developing of root .

Group Type: ACTIVE_COMPARATOR

apexification

Intervention Type: PROCEDURE

apexification uses calcium hydroxide as root medication

Interventions

revascularization

revascularization include 3 steps: root disinfected,induction of bleeding and revascularization include 3 steps: root disinfected,induction of bleeding and sealing

Intervention Type: PROCEDURE

apexification

apexification uses calcium hydroxide as root medication

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

• clinical diagnosis of periapical periodontitis
• must be immature permanent teeth
• must be local Guangzhou

Exclusion Criteria

• blood disease
• residual root that is advised to extract
• serious periodontitis
• women in pregnancy

• Minimum Eligible Age: 6 Years
• Maximum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Sun Yat-sen University

OTHER

Sponsor Role: collaborator

Junqi Ling

OTHER

Sponsor Role: lead

Responsible Party

Junqi Ling

Dean, professor

Responsibility Role: SPONSOR_INVESTIGATOR

Principal Investigators

ling j qi, PhD

Role: STUDY_CHAIR

Guanghua hospital of stomotology,Sun Yat-sen University

Locations

Guanghua hospital of stomotology,Sun Yat-sen University

Guangzhou, Guangdong, China

Site Status: RECRUITING

Countries

China

Central Contacts

Ling J Qi, PhD

Role: CONTACT

lingjq@mail.sysu.edu.cn

020-83863002

Facility Contacts

ling j q, PhD

Role: primary

lingjq@mail.sysu.edu.cn

020-83863002

References

Jung IY, Lee SJ, Hargreaves KM. Biologically based treatment of immature permanent teeth with pulpal necrosis: a case series. J Endod. 2008 Jul;34(7):876-87. doi: 10.1016/j.joen.2008.03.023. Epub 2008 May 16.

Reference Type: BACKGROUND

PMID: 18571000 (View on PubMed)

Other Identifiers

jqling

Identifier Type: REGISTRY

Identifier Source: secondary_id

5010YT

Identifier Type: -

Identifier Source: org_study_id