Comparison of Pre-exercise Beta-hydroxy-beta-methylbutyrate Free Acid (HMB-FA) and Cold Water Therapy for the Attenuation of Muscle Damage and Soreness
NCT ID: NCT01793779
Last Updated: 2013-08-01
Study Results
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Basic Information
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COMPLETED
NA
40 participants
INTERVENTIONAL
2012-12-31
2013-04-30
Brief Summary
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1. Compare beta-hydroxy-beta-methylbutyrate free acid (HMB-FA) to cold water immersion on performance recovery from an acute bout of high intensity resistance exercise.
2. Compare HMB-FA + Cold water immersion to HMB-FA or cold water immersion.
3. Examine the effect of these recovery modalities on markers of muscle damage, inflammation and immune function.
Subjects
Subjects (men and women, 18 - 35 y) with at least one year of resistance training experience will be recruited. Subjects will be randomly divided into one of four groups: a cold water immersion group (CW), HMB-FA, CW+HMB-FA and a control group (CT).
Study Protocol
Subjects will report to the Human Performance Laboratory (HPL) on four separate occasions. On the first visit (T1) subjects will be tested for maximal strength \[one repetition-maximum (1-RM)\] on the squat, dead lift and barbell lunge exercises.\] On their second visit (T2) subjects will perform a lower body resistance exercise session consisting of four sets of the squat, dead lift and barbell lunge exercises. All subjects will then report back to the HPL at 24- (T3) and 48-hours (T4) post-exercise. During T3 and T4, subjects will perform four sets of the squat exercise only using the same loading pattern and rest interval length as T2. Following the T2 and T3 workouts subjects in CT will undergo no treatment; subjects in CW will be required to sit in a whirlpool tub for 10-min up to their umbilicus in water at 50° F - 54° F (10° C - 12° C); subjects in HMB-FA will be provided the supplement 30 min prior each workout and CW+HMB-FA will be administered together at time points describe above.
Statistical Analysis
Statistical evaluation of performance and biochemical changes will be accomplished using a repeated measures analysis of variance (ANOVA).
Detailed Description
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Conditions
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Study Design
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RANDOMIZED
FACTORIAL
BASIC_SCIENCE
DOUBLE
Study Groups
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Control
Placebo supplement given prior to exercise and two times per day following exercise
Placebo
cold water immersion
Placebo supplement to be give prior to exercise and two times per day following exercise in combination with cold water immersion therapy following exercise
cold water immersion
Placebo
HMB-FA
beta-hydroxy-beta-methylbutyrate free acid supplement to be give prior to exercise and two times per day following exercise
beta-hydroxy-beta-methylbutyrate free acid (HMB-FA)
cold water immersion group + HMB-FA
beta-hydroxy-beta-methylbutyrate free acid supplement give prior to exercise and two times per day following exercise in combination with cold water immersion therapy following exercise
cold water immersion
beta-hydroxy-beta-methylbutyrate free acid (HMB-FA)
Interventions
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cold water immersion
beta-hydroxy-beta-methylbutyrate free acid (HMB-FA)
Placebo
Eligibility Criteria
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Inclusion Criteria
* Free of any physical limitations (determined by health and activity questionnaire).
* Between the ages of 18 and 35
Exclusion Criteria
* Taking any other nutritional supplement or performance enhancing drug (determined from health and activity questionnaire).
* Any chronic illness that causes continuous medical care
* Taking any type of prescription or over-the-counter medication, having any chronic illness causing you to seek medical care, pregnancy
18 Years
35 Years
ALL
Yes
Sponsors
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Metabolic Technologies Inc.
INDUSTRY
Responsible Party
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Locations
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University of Central Florida, Sport and Exercise Science
Orlando, Florida, United States
Countries
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References
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Ascensao A, Leite M, Rebelo AN, Magalhaes S, Magalhaes J. Effects of cold water immersion on the recovery of physical performance and muscle damage following a one-off soccer match. J Sports Sci. 2011 Feb;29(3):217-25. doi: 10.1080/02640414.2010.526132.
Fuller JC Jr, Sharp RL, Angus HF, Baier SM, Rathmacher JA. Free acid gel form of beta-hydroxy-beta-methylbutyrate (HMB) improves HMB clearance from plasma in human subjects compared with the calcium HMB salt. Br J Nutr. 2011 Feb;105(3):367-72. doi: 10.1017/S0007114510003582. Epub 2010 Dec 7.
Other Identifiers
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MTI2013-CS01
Identifier Type: -
Identifier Source: org_study_id