The Effect of Aerobic Exercise on Cognitive Function and Sleep Quality in Individuals With Multiple Sclerosis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

28 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-08-31

Study Completion Date

2015-12-31

Brief Summary

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In addition to the typical motor and sensory impairments, individuals with multiple sclerosis (MS) often experience cognitive dysfunction and sleep disturbances. Cognitive impairment occurs in 40 % - 70% of patients with MS. In addition, sleep problems in individuals with MS are very common, and approximately 50% of patients with MS have a diagnosable sleep disorder. The research believes that aerobic exercise improve cognitive function and improve sleep quality.

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Detailed Description

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Conditions

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Multiple Sclerosis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Aerobic Exercise

3x/week supervised moderate intensity aerobic exercise on recumbent stepper

Group Type EXPERIMENTAL

aerobic exercise

Intervention Type OTHER

Home exercise program

Walking and stretching exercises performed 3x/week for 30 minutes at intensity considered non-aerobic

Group Type ACTIVE_COMPARATOR

home exercise program

Intervention Type OTHER

Interventions

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aerobic exercise

Intervention Type OTHER

home exercise program

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* diagnosis of relapsing remitting or secondary progressive MS
* score 3-7 on the EDSS
* score \< 55 on the Symbol Digit Modalities Test
* score \> 5 on the Pittsburgh Sleep Quality Index

Exclusion Criteria

* history of alcohol/drug abuse or nervous system disorder other than MS
* severe physical, neurological, or sensory impairments that would interfere significantly with testing
* developmental history of learning disability or attention-deficit/hyperactivity disorder
* relapse and/or corticosteroid use within four weeks of assessment
* unable to give consent
* uncorrected vision loss that would interfere significantly with testing
* score less than 24 on MMSE
* Acute ischemic cardiovascular event or coronary artery bypass surgery less than 3 months ago
* Either unable to physically perform the exercise test using the recumbent stepper or demonstrate absolute indications for terminating exercise that follows the American College of Sports Medicine's (ACSM) guidelines
* Uncontrolled blood pressure with medication (BP \> 190/110mmHg)

Minimum Eligible Age

21 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No