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Exercise as a Strategy to Treat Cognitive Dysfunction in Persons With Multiple Sclerosis

NCT ID: NCT01219647

Last Updated: 2014-12-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1/PHASE2

Total Enrollment

35 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-07-31

Study Completion Date

2014-08-31

Brief Summary

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Many persons with Multiple Sclerosis ( MS) have problems with memory and thinking.Exercise has been shown to improve memory and thinking in persons with diseases such as Alzheimer's. This study will investigate whether a program of aerobic exercise can improve memory and thinking in persons with MS

Detailed Description

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Persons with Multiple Sclerosis(MS)will be screened for eligibility and randomized to a protocol with two intervention arms. One group will have aerobic training on a recumbent cross trainer three times a week for 20-30 minutes/session. The other group will participate in stretching exercises at the same frequency and intensity.Total training time will be six months.Outcome measures will include tests of memory and thinking, and fitness measures.

Conditions

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Multiple Sclerosis

Keywords

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Multiple Sclerosis Exercise Cognition

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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aerobic exercise

Subjects will train on a recumbent cross trainer 20-30 minutes/session for three times/week for six months under supervision of a fitness specialist

Group Type EXPERIMENTAL

exercise

Intervention Type BEHAVIORAL

subjects will participate in one of two forms of exercise

stretching

Subjects will particiate in supervised stretching at same frauency, duration and intensity of aerobic exericse arm

Group Type ACTIVE_COMPARATOR

stretching

Intervention Type BEHAVIORAL

subjects will particiopate in supervised stretching as described in arm description.

Interventions

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exercise

subjects will participate in one of two forms of exercise

Intervention Type BEHAVIORAL

stretching

subjects will particiopate in supervised stretching as described in arm description.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Clinical Diagnosis of MS Complaints of cognitive problems Able to ride a recumbent cross trainer

Exclusion Criteria

* Cardiopulmonary or structural disease that would limit ability to participate in exercise training On treatment with chemotherapy or natalizumab Screening score of \>50 on PASAT
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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California State University, Northridge

OTHER

Sponsor Role collaborator

University of California, Los Angeles

OTHER

Sponsor Role lead

Responsible Party

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Barbara Giesser

Clincial Profesor of Neurology

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Barbara Giesser, MD

Role: PRINCIPAL_INVESTIGATOR

University of California, Los Angeles

Locations

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UCalifornia at Los Angeles

Los Angeles, California, United States

Site Status

CAl State University at Northridge

Northridge, California, United States

Site Status

Countries

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United States

Other Identifiers

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RG 4174A5/2

Identifier Type: -

Identifier Source: org_study_id