Effects of tDCS and Cognitive Rehabilitation on Cognition and Neural Plasticity in MS Patients
NCT ID: NCT07160218
Last Updated: 2025-09-08
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
45 participants
INTERVENTIONAL
2024-01-02
2025-08-15
Brief Summary
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The main questions it aims to answer are:
Does tDCS applied over the left dorsolateral prefrontal cortex improve cognitive abilities in MS patients?
Does the combination of tDCS and cognitive rehabilitation enhance neuroplasticity, as measured by DTI, BDNF levels, and acetylcholinesterase activity?
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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tDCS
A 30-minute tDCS session with the cathode placed over the left dorsolateral prefrontal cortex (DLPFC)
tDCS
A 30-minute tDCS session with the cathode placed over the left dorsolateral prefrontal cortex (DLPFC), delivered in 10 sessions over 2 weeks. This protocol targets cognitive improvement in MS patients
tDCS+Cognitive training
A 30-minute tDCS session with the cathode over the left DLPFC combined with computer-based cognitive rehabilitation training
tDCS
A 30-minute tDCS session with the cathode placed over the left dorsolateral prefrontal cortex (DLPFC), delivered in 10 sessions over 2 weeks. This protocol targets cognitive improvement in MS patients
Cognitive Rehabilitation
computer-based cognitive rehabilitation exercises. Conducted in 10 sessions over 2 weeks to enhance attention, memory, and neuroplasticity in MS patients.
Sham tDCS
Sham stimulation applied over the left DLPFC, mimicking the sensation of tDCS without delivering active current
Sham tDCS
Sham stimulation applied over the left DLPFC for 30 minutes, mimicking the sensation of tDCS without delivering active current, over 10 sessions, used as control to blind participants to the intervention
Interventions
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tDCS
A 30-minute tDCS session with the cathode placed over the left dorsolateral prefrontal cortex (DLPFC), delivered in 10 sessions over 2 weeks. This protocol targets cognitive improvement in MS patients
Cognitive Rehabilitation
computer-based cognitive rehabilitation exercises. Conducted in 10 sessions over 2 weeks to enhance attention, memory, and neuroplasticity in MS patients.
Sham tDCS
Sham stimulation applied over the left DLPFC for 30 minutes, mimicking the sensation of tDCS without delivering active current, over 10 sessions, used as control to blind participants to the intervention
Eligibility Criteria
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Inclusion Criteria
Diagnosed with relapsing-remitting multiple sclerosis (RRMS).
Mild disability, defined as EDSS \< 5.
Patients who attended the neurology clinic and are willing to participate.
Exclusion Criteria
History of seizures.
Left-handed individuals.
Recent MS relapse requiring steroid treatment.
Pregnant women.
History of brain surgery or presence of intracranial clips.
20 Years
50 Years
ALL
No
Sponsors
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Shahid Beheshti University of Medical Sciences
OTHER
Responsible Party
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Mehrdad Roozbeh
Assistant Professor of Neurology
Locations
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Shahid Beheshti University of Medical Science
Tehran, , Iran
Countries
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Other Identifiers
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IR.SBMU.PHNS.REC.1402.121
Identifier Type: -
Identifier Source: org_study_id
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