Effects of Phenolic Acids on Endothelial Function

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

24 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-06-30

Study Completion Date

2012-11-30

Brief Summary

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Epidemiological studies suggest dietary (poly) phenols decrease the risk of death from cardiovascular diseases. (Poly)phenol-rich foods include fruits and vegetables as well as tea, coffee, red wine, and chocolate. The aim of the present study is to investigate whether endothelial function is altered by ingestion of phenolic acids. Moreover, the investigators will evaluate the effect of phenolic acids on blood pressure and platelet adhesion.

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Detailed Description

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Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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phenolic acids

Maltodextrine + Phenolic acids

Group Type EXPERIMENTAL

Phenolic acids

Intervention Type OTHER

Phenolic acids

placebo

Maltodextrine

Group Type PLACEBO_COMPARATOR

Phenolic acids

Intervention Type OTHER

Phenolic acids

phenolic acid

Maltodextrine + Phenolic acids

Group Type EXPERIMENTAL

Phenolic acids

Intervention Type OTHER

Phenolic acids

polyphenol

Group Type ACTIVE_COMPARATOR

Phenolic acids

Intervention Type OTHER

Phenolic acids

Interventions

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Phenolic acids

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Healthy
* males
* Smokers

Exclusion Criteria

Any food allergy

* Abnormal blood pressure defined as follow: systolic \<100 or \>160 mmHg and diastolic \<50 or \>100mmHg
* Regular consumption of medication within 2 months before the study inclusion
* Caffeine intake 1 day before screening measurements (and 1 day before each visit),
* Any intake of multivitamin-tablets and other supplemental compounds 10 days before the study start and throughout the study.
* Excessive alcohol intake defined as \> 280 g per week

Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes