Muscle Atrophy in Patients With Severe Sepsis

NCT ID: NCT01717651

Last Updated: 2016-01-18

Basic Information

• Recruitment Status: TERMINATED
• Total Enrollment: 25 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2011-12-31
• Study Completion Date: 2013-02-28

Brief Summary

This study is being done to help determine whether patients with severe sepsis (overwhelming inflammation in the body as a result of an infection) lose muscle and become weak more rapidly than patients with other severe illnesses. Weakness and muscle loss that develops after a severe illness is a serious problem. Patients who develop weakness and have a decrease in muscle size often have to stay in the hospital longer and have a higher chance of dying. At the current time, it is not clear whether certain severe illnesses are more likely to cause weakness and muscle loss. This study will be done to measure the changes in muscle size and strength as a result of each patient's illness

Detailed Description

An optional portion of the study is available to help determine if moving the leg repeatedly with a mechanical device helps prevent muscle loss and weakness. In this optional portion of the study, the subject would have a CPM (continuous passive motion) device attached to one of the subject's legs intermittently over the next three days. Without any effort from the subject , the machine would move the subjects leg back and forth (flexing at the hip and the knee) repeatedly.

This machine is approved by the United States Food and Drug Administration (FDA) to treat patients after they have knee replacement surgery to help preserve the range of motion of the joint while minimizing risk of damage to the joint from more intensive exercise. The use of the device for this study is investigational.

Conditions

Severe Sepsis; Respiratory Failure

Study Design

• Observational Model Type: CASE_ONLY
• Study Time Perspective: PROSPECTIVE

Study Groups

CPM device

a CPM (continuous passive motion) device attached to one of your legs intermittently over the next three days.

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

1. Age ≥ 18 years

2. Required mechanical ventilation for at least 24 hours

Exclusion Criteria

1. Ventilator liberation anticipated in the next 24 hours

a. Rationale: short duration of illness anticipated, preventing achievement of primary endpoint

2. Known or suspected acute diagnosis of neuromuscular disease causing diffuse or lower extremity weakness (e.g. CVA, spinal cord injury or lesion, Muscular dystrophy, Myasthenia Gravis, GBS)

a. Rationale: chronic lower extremity weakness will impact anticipated physical recovery and relevance of atrophy observations

3. Pre-existing lower extremity weakness caused by prior injury, neuromuscular or joint disease

a. Rationale: Inability to participate in usual care therapy and CPM. Impacts functional recovery

4. Wounds, dressings or injuries of the lower extremities or pelvis that prevent muscle testing or CPM

a. Rationale: Inability to participate in US, exam or CPM

5. Patient's family, physician, or both not in favor of aggressive treatment of patient that includes life-sustaining treatments or the presence of an advance directive indicating the same a. Rationale: Unlikely to survive to seven day endpoint

6. More than seventy-two hours of continuous mechanical ventilation previously during this hospitalization

a. Rationale: Atrophy mechanisms already active and may degrade ability to detect early changes.

7. Non-English speaking subject or legally authorized representative

a. Rationale: This study does not have the funding necessary to translate consents and inability to ensure cooperation with testing.

8. Subject and/or Legally authorized representative unavailable to provide informed consent

9. Subject is a Prisoner

10. Pregnancy (excluded from CPM portion only) a. Rationale: Pregnant patients can develop the supine hypotensive syndrome (where the uterus compromises venous return due to compression of the IVC). This typically occurs only after 20 weeks gestation. To assure safety, any patient who self identifies as pregnant or has a positive urine pregnancy test on admission will not be offered CPM since it requires extended periods in the supine position.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Ohio State University

OTHER

Sponsor Role: lead

Responsible Party

Naeem Ali, MD

Medical Director, Medical Intensive Care Unit (MICU);

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Naeem A Ali, MD

Role: PRINCIPAL_INVESTIGATOR

Ohio State University

Locations

The Ohio State University Medical Center - University Hospital

Columbus, Ohio, United States

Countries

United States

Other Identifiers

2011H0290

Identifier Type: -

Identifier Source: org_study_id