Identification of New Markers in the Hypereosinophilic Syndrome

NCT ID: NCT01713504

Last Updated: 2026-01-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

41 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-06-29

Study Completion Date

2015-07-31

Brief Summary

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The purpose is to characterize new hypereosinophilic syndrome biomarkers more informative and more accessible compared to those that we have already thanks to a proteomic approach. This will help the investigators to diagnose the this disease.

Detailed Description

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Conditions

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Hypereosinophilic Syndrome

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Hypereosinophilic syndrome unexplained

Group Type EXPERIMENTAL

biologie sample

Intervention Type BIOLOGICAL

comparison of biomarkers between HES, HE biomarkers data and control arms

Hypereosinophilic syndrome explained

Group Type ACTIVE_COMPARATOR

biologie sample

Intervention Type BIOLOGICAL

comparison of biomarkers between HES, HE biomarkers data and control arms

Normal rate of eosinophilic

Group Type SHAM_COMPARATOR

biologie sample

Intervention Type BIOLOGICAL

comparison of biomarkers between HES, HE biomarkers data and control arms

Interventions

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biologie sample

comparison of biomarkers between HES, HE biomarkers data and control arms

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* dated and signed informed consent
* virale serology negative or negative result less than 6 months
* virale serology negative for HBV or vaccinated patient
* insured
* virale serology negative or negative result less than 6 months
* negative pregnancy test or female menopause for at least 1 year

Exclusion Criteria

* subject enable adult, under guardianship or under protective measures of justice
* Refusal or inability to give informed consent
* The hypereosinophilic syndrome explained origin other than than atopy, bullous pemphigoid, the Churg-Strauss syndrome and DRESS
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University Hospital, Lille

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Lionel Prin, MD PhD

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Lille

Locations

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CHRU, Hôpital Claude Huriez

Lille, Nord, France

Site Status

Countries

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France

References

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Lefevre G, Copin MC, Roumier C, Aubert H, Avenel-Audran M, Grardel N, Poulain S, Staumont-Salle D, Seneschal J, Salles G, Ghomari K, Terriou L, Leclech C, Morati-Hafsaoui C, Morschhauser F, Lambotte O, Ackerman F, Trauet J, Geffroy S, Dumezy F, Capron M, Roche-Lestienne C, Taieb A, Hatron PY, Dubucquoi S, Hachulla E, Prin L, Labalette M, Launay D, Preudhomme C, Kahn JE; French Eosinophil Network. CD3-CD4+ lymphoid variant of hypereosinophilic syndrome: nodal and extranodal histopathological and immunophenotypic features of a peripheral indolent clonal T-cell lymphoproliferative disorder. Haematologica. 2015 Aug;100(8):1086-95. doi: 10.3324/haematol.2014.118042. Epub 2015 Feb 14.

Reference Type RESULT
PMID: 25682606 (View on PubMed)

Other Identifiers

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2009-A00314-53

Identifier Type: OTHER

Identifier Source: secondary_id

2008_29

Identifier Type: -

Identifier Source: org_study_id

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