Discovery and Validation of Proteogenomic Biomarker Panels in Liver Transplant Recipients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

202 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-08-31

Study Completion Date

2015-12-31

Brief Summary

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The main focus of this study is to develop blood and/or urine tests that will help to detect early signs of rejection in people who have had a liver transplant. Researchers will examine blood, urine, and tissue samples and try to identify markers for certain conditions such as rejection, response to therapy, and scarring of the liver. Additionally, researchers would like to identify biomarkers that can detect damage to the native kidneys before blood levels of creatinine rises. By studying gene expression, researchers hope to be able to diagnose these conditions earlier and improve liver survival.

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Detailed Description

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Conditions

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Liver Transplant Recipients Liver Transplantation

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Liver Transplant Recipients

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Subjects undergoing primary deceased-donor or living donor liver transplantation;
* Subject must be able to understand and provide informed consent.

Exclusion Criteria

* Need for combined organ transplantation;
* Previous solid organ and/or islet cell transplantation;
* Infection with HIV;
* Allergy to iodine;
* Inability or unwillingness of a participant to comply with study protocol;
* Any condition that, in the opinion of the investigator, would interfere with the participant's ability to comply with study requirements.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No