Gene Polymorphism of IL17 and IL 23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

120 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-06-03

Study Completion Date

2021-12-03

Brief Summary

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rates are in such considerable amount among large population base. The pathogenesis of COVID-19 implicates a potent inflammatory response, involving a complex group of mediators including interleukins. These pleiotropic cytokines are secreted at the region of inflammation and released into the circulation by a variety of different cell types, including macrophages, lymphocytes, endothelial cells, epithelial cells during sepsis and acute organ injuries. There has recently found a number of studies reporting that the cytokine storms take part in the course of COVID-19

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Detailed Description

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Aim Of The Study

1. To evaluate if there is an association between the IL-17, IL-23 gene polymorphism in Patients With COVID 19 by real-time PCR
2. To measure the serum level of IL17 by ELISA in COVID 19 patients by ELISA.
3. To detect if there is an association between gene polymorphism of IL17 and IL23 and severity of a condition in patients with COVID 19 Study design: a cross-sectional study.

The blood samples will be collected from patient records in COVID19 isolation hospitals in sohag governorate and isolation department in sohag university hospitals.

Conditions

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COVID-19 Respiratory Infection

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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group 1 patients with severe covid 19 respiratory infections

Patients with severe covid 19 admitted to ICU, blood samples will be collected for testing different genotypes and serum level of IL 17

laboratory test

Intervention Type DIAGNOSTIC_TEST

genotyping of IL 17 and IL23

laboratory test

Intervention Type DIAGNOSTIC_TEST

estimation of serum level of IL 17

group 2 patients with non severe covid 19 respiratory infections

Patients with nonsevere covid 19 admitted to the internal ward, blood samples will be collected for testing different genotypes and serum level of IL 17