Urinary Cytokine Levels as a Prognostic Marker for Kidney Scarring After Pyelonephritis

NCT ID: NCT00868270

Last Updated: 2009-03-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

35 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-05-31

Brief Summary

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The prevalence of kidney scarring after UTI is approximately 5-57%. UTIs are caused mainly by bacteria that cause local and systemic immunological reaction that are accompanied by cytokines. These cytokines are a main factor in the inflammatory process. They are produced by leukocytes, macrophages, fibroblasts, endothelial cells and epithelial cells in the kidney tissue. Interleukin 6 and 8 (IL-6 IL-8) were found in high levels in the urine of children and adults who suffer from UTIs. Other studies on animals have found a relationship between inflammatory reaction and scarring in the kidney. We hypothesize that we will find a similar relationship between the level of IL-6, IL-8 in the urine during acute pyelonephritis in children and the probability of kidney scarring.

Detailed Description

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Conditions

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Kidney Scarring Post-Febrile UTI

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Children with UTIs

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Children aged 0-7
* First episode febrile UTI

Exclusion Criteria

* Recurrent UTI
Maximum Eligible Age

7 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hillel Yaffe Medical Center

OTHER_GOV

Sponsor Role lead

Responsible Party

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Pediatrics Dept. Hillel Yaffe Medical Center

Locations

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Hillel Yaffe Medical Center

Hadera, , Israel

Site Status

Countries

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Israel

Central Contacts

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Hassan Jassar, MD

Role: CONTACT

972-4-630-4332

Facility Contacts

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Hassan Jassar, MD

Role: primary

Other Identifiers

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HY55-08

Identifier Type: -

Identifier Source: org_study_id

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