Hyponatremia and Myometrium Contractility. An Invitro Study

NCT ID: NCT01708811

Last Updated: 2015-10-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Total Enrollment

12 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-10-31

Study Completion Date

2015-10-31

Brief Summary

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Hyponatremia during labour has been associated with prolonged labour, and increased incidence of instrumental delivery and emergency caesarean section. Sodium influx in myometral cells are involved in contractility,and and influence of hyponatraemia on contractility can be suspected.

Detailed Description

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Biopsies will be obtained from pregnant women undergoing planned caesarean section at term. The biopsies will divided into 3 strips that will be stored overnight in chilled NaCl 0.9%. The following morning each strip will be mounted isometrically with one end fixed to a holder and the other end to a force transducer. One strip will be maintained in a solution containing 140mmol/L Na,acting as control, whereas the other two strips will be placed in fluids with diminishing Na concentration, from 140 mmol/L, to 130 mmol/L and 120 mmol/L. Contractility will be measured with force transducers and a polygraph

Conditions

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Hyponatremia

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Singleton pregnancy at term

Exclusion Criteria

* Preeclampsia
Minimum Eligible Age

18 Years

Maximum Eligible Age

48 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Karolinska University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Vibeke Moen

research fellow

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Gunvor Ekman-Ordeberg, PhD

Role: PRINCIPAL_INVESTIGATOR

Department of Women and Child´s Healt, karolinska University Hospital, Solna, Stockholm, Sweden

Locations

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Department of Women and Child´s Health, Karolinska University Hospital, Solna

Stockholm, Stockholm County, Sweden

Site Status

Countries

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Sweden

References

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Moen V, Brudin L, Rundgren M, Irestedt L. Hyponatremia complicating labour--rare or unrecognised? A prospective observational study. BJOG. 2009 Mar;116(4):552-61. doi: 10.1111/j.1471-0528.2008.02063.x. Epub 2009 Jan 27.

Reference Type BACKGROUND
PMID: 19175600 (View on PubMed)

Kamizaki J, Shimizu K, Nakajyo S, Urakawa N. A comparative study on the contraction induced by high K+/Na+ deficient solution in rat uterus or urinary bladder. Jpn J Pharmacol. 1988 Jun;47(2):179-88. doi: 10.1254/jjp.47.179.

Reference Type BACKGROUND
PMID: 3199594 (View on PubMed)

Sperelakis N, Inoue Y, Ohya Y. Fast Na+ channels and slow Ca2+ current in smooth muscle from pregnant rat uterus. Mol Cell Biochem. 1992 Sep 8;114(1-2):79-89.

Reference Type BACKGROUND
PMID: 1281264 (View on PubMed)

Cheek TG, Samuels P, Miller F, Tobin M, Gutsche BB. Normal saline i.v. fluid load decreases uterine activity in active labour. Br J Anaesth. 1996 Nov;77(5):632-5. doi: 10.1093/bja/77.5.632.

Reference Type BACKGROUND
PMID: 8957980 (View on PubMed)

Garite TJ, Weeks J, Peters-Phair K, Pattillo C, Brewster WR. A randomized controlled trial of the effect of increased intravenous hydration on the course of labor in nulliparous women. Am J Obstet Gynecol. 2000 Dec;183(6):1544-8. doi: 10.1067/mob.2000.107884.

Reference Type BACKGROUND
PMID: 11120525 (View on PubMed)

Other Identifiers

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LOF-KS1

Identifier Type: -

Identifier Source: org_study_id

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