Colloid Preload Versus Crystalloid Co-load in Cesarean Section Under Spinal Anesthesia

NCT ID: NCT03107598

Last Updated: 2017-04-11

Basic Information

• Recruitment Status: TERMINATED
• Clinical Phase: NA
• Total Enrollment: 127 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2016-03-31
• Study Completion Date: 2016-09-30

Brief Summary

Comparison between colloid preload and crystalloid co-load in cesarean section under spinal anesthesia.

1. The primary outcome was the incidence of hypotension

2. Secondary outcomes included the incidence of severe hypotension, total ephedrine dose, nausea and vomiting and neonatal outcome assessed by Apgar scores and umbilical artery blood gas analysis

Detailed Description

It's a prospective randomized study, during 7 months between march and September 2016, carry on department of anesthesia and intensive care and department of obstetrics and gynecology, at Taher Sfar Mahdia University Hospital. investigators included participants:

• Aged between 18 and 40 years' old
• American Society of Anesthesiologists physical status I or II (ASA)
• Full-term singleton pregnancy
• scheduled for elective cesarean section under spinal anesthesia

Parturients were excluded if :

• participants younger than 18 or older than 40 years
• cardiovascular, cerebrovascular or renal disease
• multiple gestations
• polyhydramnios or known fetal abnormalities
• allergy to local anesthetics or opioids
• emergency Cesarean section or parturient that have failed vaginal delivery with epidural analgesia
• contraindications for performing spinal anesthesia in this study no premedication was given. Patients entered the operating room and lay supine with 15° of left lateral tilt on the operating table.

Standard monitors of electrocardiography, pulse oximetry (Spo2), and noninvasive blood pressure were applied on the right arm.

Baseline systolic and diastolic blood pressure (SBP, DPB) and heart rates (HR) were recorded. An 18 or 16-gauge intravenous cannula was inserted in a large forearm vein.Patients were randomly assigned into two groups: colloid preload (CoP), and crystalloid co-load (CrC).Group CoP: group with colloid preload The preload group received rapid infusion of 15ml/kg of 6% hydroxyethyl starch (6% HES, voluven) administered by gravity at a wide-open rate over a period of 15-30min before induction of spinal anesthesia.Group CrC: group with crystalloid coload received a sodium chloride 0.9% perfusion as rapidly as possible starting at the time of intrathecal injection.

Spinal anesthesia was performed in the sitting position with a 27- or 25-gauge spinal needle at the L3-4 or L2-3 interspace using hyperbaric bupivacaine 10 mg (0.5% hyperbaric bupivacaine 2 mL), sufentanyl 2.5 µg (0.5 ml) and 100µg morphine (1ml). All patients received the same dose regardless of height or weight. After completing the anesthetic procedure, patients were immediately repositioned to supine with a 15°-30° left lateral tilt. The highest sensory block was checked and confirmed at the level of T3-T5 determined with loss-to-pinprick method bilaterally at 5 minutes and 10 minutes after spinal drug administration. Motor block was measured with modified Bromage scale (0, no block; 1, inability to raise extended leg;2, inability to flex knee; 3, inability to flex ankle and foot).

Oxygen was routinely given: 5 l/min was administrated via a clear facemask. After umbilical cord clamping, prophylactic antibiotic treatment was administrated intravenously whether 2g of cefazolin or 600mg of clindamycin if the parturient was allergic to penicillin.After delivery of the baby, 10 UI of oxytocin was intravenously given, and 15 UI was titrated following lactate ringer's solution.

Hypotension was defined as a 20% reduction of systolic blood pressure from baseline .Severe hypotension defined as SBP < 80 mmhg.

It was treated with an intravenous ephedrine bolus:

• 70% ≤ SBP < 80% from baseline value: ephedrine 6mg
• SBP < 70% from baseline value: ephedrine 9mg
• SBP < 60% from baseline value: ephedrine 12mg Vasopressor treatment was repeated every 2 minutes if hypotension persisted or recurred.

Conditions

Hypotension

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: PREVENTION
• Blinding Strategy: SINGLE

Study Groups

colloid preload

Group CoP: group with colloid preload The preload group received rapid infusion of 15ml/kg of 6% hydroxyethyl starch (6% HES) administered by gravity at a wide-open rate over a period of 15-30min before induction of spinal anesthesia.

Group Type: EXPERIMENTAL

colloid preload

Intervention Type: DRUG

coparaison between colloid and crystalloide loading in spinal anesthesia for cesarean section

crystalloid coload

Group CrC: group with crystalloid coload The coload group received a sodium chloride 0.9% perfusion as rapidly as possible starting at the time of intrathecal injection for spinal anesthesia.

Group Type: PLACEBO_COMPARATOR

colloid preload

Intervention Type: DRUG

coparaison between colloid and crystalloide loading in spinal anesthesia for cesarean section

Interventions

colloid preload

coparaison between colloid and crystalloide loading in spinal anesthesia for cesarean section

Intervention Type: DRUG

Other Intervention Names

crystalloid coload

Eligibility Criteria

Inclusion Criteria

• Aged between 18 and 40 years' old
• American Society of Anesthesiologists physical status I or II (ASA)
• Full-term singleton pregnancy
• scheduled for elective cesarean section under spinal anesthesia

Exclusion Criteria

• cardiovascular, cerebrovascular or renal disease
• multiple gestations
• polyhydramnios or known fetal abnormalities
• allergy to local anesthetics or opioids
• emergency Cesarean section or parturient that have failed vaginal delivery with epidural analgesia
• contraindications for performing spinal anesthesia

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 40 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: Yes

Sponsors

University Hospital, Mahdia

OTHER

Sponsor Role: lead

Responsible Party

Majdoub Ali MD

head of anesthesia department clinical professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Other Identifiers

LCS

Identifier Type: -

Identifier Source: org_study_id