Comparison of Norepinephrine and Ephedrine on Hypotension After Spinal Anesthesia in Parturients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

66 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-10-05

Study Completion Date

2016-06-30

Brief Summary

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Incidence of hypotension is high in parturients after spinal anesthesia. Ephedrine could be used to treat hypotension but lead to lower fetal pH as well. This study is to compare the effects of norepinephrine and ephedrine on hypotension in parturients.

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Detailed Description

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Spinal anesthesia is an accepted technique in elective cesarean sections. However, hypotension, resulted from sympathectomy is a common problem, especially in pregnant women. Prevention of this complication by sympathomimetic agents is of potential clinical significance. Ephedrine could be used to treat hypotension but lead to lower fetal pH, which may be related to worse fetal outcome.Norepinephrine could improve the hypotension to the same extent as phenylephrine. In this study, we tend to compare the effects of norepinephrine and ephedrine on hypotension in parturients and on fetal acid status.

Conditions

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Hypotension Obstetrical Complication of Anesthesia Complications; Cesarean Section

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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norepinephrine

norepinephrine is injected after spinal anesthesia

Group Type EXPERIMENTAL

Norepinephrine

Intervention Type DRUG

norepinephrine injection

ephedrine

ephedrine is injected after spinal anesthesia

Group Type OTHER

Ephedrine

Intervention Type DRUG

Ephedrine injection

Interventions

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Norepinephrine

norepinephrine injection

Intervention Type DRUG

Ephedrine

Ephedrine injection

Intervention Type DRUG

Other Intervention Names

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vasoactive agents vasoactive agents

Eligibility Criteria

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Inclusion Criteria

* Patients scheduled for elective cesarean section

Exclusion Criteria

* Patients with severe pre-eclampsia
* Patients with contraindications for spinal anesthesia
* Patients with multiple pregnancy
* Patients with gestation \<38w

Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No