Optimization of the Anesthetic Regimen Using the SmartPilot® System and Influence on Different Outcome Parameters - a Pilot Study.

NCT ID: NCT01694901

Last Updated: 2019-06-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

150 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-11-12

Study Completion Date

2017-07-14

Brief Summary

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This study investigates whether general anesthesia using a Pharmacokinetic/Pharmacodynamic (PK/PD) -model-based index indicating the compound effect of different anesthetics leads to optimized outcome compared to manually controlled clinical anesthesia and computerized Electroencephalogram (EEG).

Detailed Description

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Conditions

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Postoperative Cognitive Disturbances

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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SmartPilot® system

50 patients scheduled for elective surgery (general/abdominal surgery; traumatological/orthopedic surgery, gynecology, urology) in general anesthesia using the SmartPilot® system

No interventions assigned to this group

Standard arm

50 patients scheduled for elective surgery (general/abdominal surgery; traumatological/orthopedic surgery, gynecology, urology) in general anesthesia according to the standard operating procedures of the department, i.e. manually controlled clinical anesthesia and EEG-derived parameters of anesthetic depth

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Offered patient information and written informed consent
* Male/female patients with intended ratio of 1:1
* patients aged greater than or equal to 60 years
* scheduled duration of surgery longer than or equal to 60 minutes
* elective surgery (general/abdominal surgery, traumatological/orthopedic surgery, gynecology, urology) in general anesthesia

Exclusion Criteria

* Persons without the capacity to consent
* Unability of German language use
* Lacking willingness to save and hand out data within the study
* Participation in another study according to the German Medicinal Products Act within 30 days before participation in the Smart-Outcome study
* Accommodation in an institution due to an official or judicial order
* (Unclear) history of alcohol or substances disabuse
* Member of staff of the Charité
* Neurological or psychiatric disease
* American Society of Anaesthesiologists (ASA) classification greater than or equal to class IV
* Moribund patients

Due to the underlying PKPD models of the SmartPilot® system, patient with the following characteristics cannot be anesthetized using SmartPilot®:

* Height \< 150 or \> 200 cm, respectively
* Weight \< 40 or \> 140 kg, respectively
* Body Mass Index \> 30
* Age \< 18 or \> 90 years of age, respectively
Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Claudia Spies

OTHER

Sponsor Role lead

Responsible Party

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Claudia Spies

Prof. Dr. C. Claudia

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Spies Claudia, MD, Prof.

Role: STUDY_DIRECTOR

Charite University, Berlin, Germany

Locations

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Department of Anesthesiology and Intensive Care Medicine, Campus Virchow Klinikum, Charité - Universitätsmedizin

Berlin, , Germany

Site Status

Countries

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Germany

Other Identifiers

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Smart-Outcome

Identifier Type: -

Identifier Source: org_study_id

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