Pseudoexfoliation and Chronic Kidney Disease

NCT ID: NCT01693744

Last Updated: 2012-09-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

358 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-10-31

Study Completion Date

2012-04-30

Brief Summary

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Background: Pseudoexfoliation (PEX) is characterised by the deposition of fibrillar material in an eye structures and many other parts of the body including kidneys and blood vessels. As both PEX and chronic kidney disease (CKD) are associated with oxidative stress and endothelial dysfunction we studied if the risk of PEX was increased in patients with CKD.

Methods: Patients over age 40 with the diagnosis of CKD were included in the study. Chronic kidney disease was diagnosed as decreased glomerular filtration rate (GFR) of less than 60 mL/min/1.73 m². Study groups were arranged as group 1 consisting of HD receiving patients, group 2 consisting of stage 1-4 CKD patients and group 3 consisting of patients with normal kidney functions (control group). Demographic properties and the rate of PEX were evaluated and compaired between the groups.

Detailed Description

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Conditions

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Chronic Kidney Disease

Keywords

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Pseudoexfoliation, chronic kidney disease

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Dialysis patients

Patients with stage 5 chronic kidney disease undergoing haemodialysis

No interventions assigned to this group

Chronic kidney disease patients

Stage 1-4 Chronic kidney disease patients

No interventions assigned to this group

Control group

Patients with normal renal functions

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* All patients with chronic kidney disease stage 1-5

Exclusion Criteria

* History of eye trauma or surgery
Minimum Eligible Age

40 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Corum State Hospital

OTHER

Sponsor Role lead

Responsible Party

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Leyla Niyaz

Ophthalmology Specialist

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Leyla Niyaz, M.D.

Role: PRINCIPAL_INVESTIGATOR

Specialist in Ophthalmology

Locations

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Corum State Hospital

Çorum, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

Other Identifiers

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LNiyaz

Identifier Type: -

Identifier Source: org_study_id