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The Relation Between Uric Acid Level and Endothelial Dysfunction in Patients With Polycystic Kidney Disease

NCT ID: NCT01589705

Last Updated: 2012-07-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Total Enrollment

150 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-01-31

Study Completion Date

2012-04-30

Brief Summary

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There are substantial data demonstrating increased endothelial dysfunction, inflammation and oxidative stress in patients with Autosomal dominant polycystic kidney disease (ADPKD), the association between serum uric acid level and endothelial dysfunction has not been elucidated yet in these patients. Therefore, in this study, the investigators aimed to examine the relationship between the uric acid level and the ED in normotensive ADPKD patients with preserved renal function.

Detailed Description

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This is the first study to evaluate the relationship between uric acid and endothelial dysfunction in patients with early stage ADPKD

Conditions

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Polycystic Kidney, Autosomal Dominant

Keywords

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Uric acid polycystic kidney disease

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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polycystic kidney ,no hypertension

The study evaluated the association of serum uric acid levels with endothelial dysfunction in early ADPKD patients with normal renal function

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* ADPKD patients with normal renal function,
* Normotensive ADPKD patients

Exclusion Criteria

* Patients with impaired kidney function,
* Atherosclerotic disorders,
* Diagnosis of hypertension, gout, diabetes,
* Using of insulin, thiazide, allopurinol or uricosuric drugs
Minimum Eligible Age

20 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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TC Erciyes University

OTHER

Sponsor Role lead

Responsible Party

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Ismail Kocyigit

TC Erciyes University Medical School

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Bulent Tokgoz, Professor

Role: STUDY_DIRECTOR

Erciyes University Medical School

Locations

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Erciyes University Medical School

Kayseri, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

References

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Kocyigit I, Yilmaz MI, Orscelik O, Sipahioglu MH, Unal A, Eroglu E, Kalay N, Tokgoz B, Axelsson J, Oymak O. Serum uric acid levels and endothelial dysfunction in patients with autosomal dominant polycystic kidney disease. Nephron Clin Pract. 2013;123(3-4):157-64. doi: 10.1159/000353730. Epub 2013 Jul 25.

Reference Type DERIVED
PMID: 23887359 (View on PubMed)

Other Identifiers

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Erciyes 2011/273

Identifier Type: -

Identifier Source: org_study_id