Immunologic Abnormalities, Chronic Inflammation and Oxidative Stress in Chronic Kidney Disease

NCT ID: NCT00793806

Last Updated: 2022-10-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

14 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-08-31

Study Completion Date

2012-03-31

Brief Summary

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The common causes of mortality are late stages of chronic kidney disease, cardiovascular disease and infections, are associated with abnormalities of the immune system, an underlying state of chronic inflammation and oxidative stress. These processes have not been carefully described in the chronic kidney disease population. The researcher can use Diffuse Optical Spectroscopy to determine the immune system in individuals with chronic kidney disease and describe the association with chronic inflammation and oxidative stress in that population.

Detailed Description

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The Diffuse Optical Spectroscopy can measure the absolute concentrations of reduced and oxygenated hemoglobins,cardiac output, mean arterial pressure, blood loss,blood hemoglobin concentration, water and lipid concentrations of the tissue.

The researchers can use Diffuse Optical Spectroscopy to monitor volume changes during the hemodialysis treatment and to correlate the changes in volume and blood pressure with the measures of oxidative stress and inflammation used in this study. The researchers can use Diffuse Optical Spectroscopy data to compare to laboratory parameters routinely measured to clinical parameters such as cause of chronic kidney disease, blood pressure and dialysis-related parameters.

Conditions

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Chronic Kidney Disease

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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Medical Tool

Diffuse Optical Spectroscopy measurements will be compared to a variety of laboratory parameters routinely measured in Chronic Inflammation and Oxidative Stress in Chronic Kidney Disease

Diffuse Optical Spectroscopy

Intervention Type DEVICE

Diffuse Optical Spectroscopy measurements will be compared to a variety of laboratory parameters routinely measured in Chronic Inflammation and Oxidative Stress in Chronic Kidney Disease

Interventions

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Diffuse Optical Spectroscopy

Diffuse Optical Spectroscopy measurements will be compared to a variety of laboratory parameters routinely measured in Chronic Inflammation and Oxidative Stress in Chronic Kidney Disease

Intervention Type DEVICE

Other Intervention Names

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Diffuse Optical Spectroscopy measurements

Eligibility Criteria

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Inclusion Criteria

* 18 years and older with chronic kidney disease undergoing hemodialysis have been treated with hemodialysis for at least 3 months
* 18 years and older for control

Exclusion Criteria

* acute kidney disease
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Beckman Laser Institute University of California Irvine

OTHER

Sponsor Role collaborator

University of California, Irvine

OTHER

Sponsor Role lead

Responsible Party

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Beckman Laser Institute and Medical Center

Madeleine Pahl, M.D., Associate Professor of Medicine and Director of the Renal Clinic

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Madeleine Pahl, M.D.

Role: PRINCIPAL_INVESTIGATOR

University of California, Irvine

Locations

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Beckman Laser Institute

Irvine, California, United States

Site Status

University of California Medical Center: Dialysis Unit

Orange, California, United States

Site Status

UCIMC Dialysis center

Orange, California, United States

Site Status

Countries

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United States

Other Identifiers

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20075572

Identifier Type: -

Identifier Source: org_study_id

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