Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
8 participants
INTERVENTIONAL
2007-07-31
2007-08-31
Brief Summary
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8 healthy male volunteers took part in a stationary study carried out in the metabolic ward of the German Aerospace Center. The study consisted of 2 campaigns, each lasting 16 days. Both campaigns were divided into 5 days of adaptation, 10 days of intervention and 1.5 days of stationary recovery. During the intervention period the volunteers diet was NaCl-rich (7.7 mmol Na/kg body weight/day) and supplemented in one campaign by 90 mmol potassium bicarbonate (KHCO3) in a randomized cross-over design. The other campaign served as control.
Bone metabolism was studied by bone formation markers in the fasting morning blood and 24h-urinary bone resorption markers. Acid base status was assessed by blood gas analyses in the fasted and the postprandial state as well as urinary markers. Protein turnover was studied with stable isotopes. Further physiological systems like energy metabolism and the cardiovascular system are also under investigation.
Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
NONE
Study Groups
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Campaign 1
High NaCl + KHCO3
7.7 mmol Na/kgBW/d + 90 mmol KHCO3
Control: high NaCl
7.7 mmol Na/kgBW/d
Campaign 2
High NaCl + KHCO3
7.7 mmol Na/kgBW/d + 90 mmol KHCO3
Control: high NaCl
7.7 mmol Na/kgBW/d
Interventions
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High NaCl + KHCO3
7.7 mmol Na/kgBW/d + 90 mmol KHCO3
Control: high NaCl
7.7 mmol Na/kgBW/d
Eligibility Criteria
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Inclusion Criteria
* 19 - 35 years
* 65 - 85kg
* 170 - 190 cm
* successfully completed psychological and medical screening
Exclusion Criteria
* smoking
* drug- or alcohol abuse
* hyperlipidemia
* renal diseases
* obesity
* anemia
* bone diseases
* diabetes
* rheumatism
* blood donation within three month prior to study start
* participation in another clinical investigation three month prior to study start
19 Years
35 Years
MALE
Yes
Sponsors
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Charite University, Berlin, Germany
OTHER
University of Erlangen-Nürnberg
OTHER
DLR German Aerospace Center
OTHER
Responsible Party
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Locations
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German Aerospace Center (DLR)
Cologne, , Germany
Countries
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Other Identifiers
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DLR Salty Life 8 Study
Identifier Type: -
Identifier Source: org_study_id