Reduction of Metabolic Acidosis in Patients With Chronic Kidney Disease in Stage 4 and 5
NCT ID: NCT05970094
Last Updated: 2023-12-04
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
20 participants
INTERVENTIONAL
2023-03-06
2023-11-20
Brief Summary
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The hypothesize is, that an acid/base diet will reduce the degree of acidosis and the need for oral bicarbonate supplements.
Detailed Description
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Participants will be asked to follow a restricted diet with a low "PRAL" during a 6 week trial divided in three periodes: two week free living control, two week intervention and a two week free living follow-up.
The PRAL calculation tool will be used to create a diet low in acid, based on this the patients will receive individual diet plans. The diet will comply with national treshold guidelines for potassium and protein, this is due to the high risk of hyperkalemia in patients with chronic kidney disease. The patients will be asked to document their food and drink intake by taking pictures of their plates and cups before and after a meal, over a 24 hour period.
Conditions
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Keywords
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Study Design
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NA
SINGLE_GROUP
TREATMENT
NONE
Study Groups
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Low PRAL diet
Crossover design: 1 arm consisting of three consecutive periods of two weeks (control, intervention and follow up).
Low PRAL
Two weeks on a low PRAL diet compared to 2 week free living
Interventions
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Low PRAL
Two weeks on a low PRAL diet compared to 2 week free living
Eligibility Criteria
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Inclusion Criteria
* Diagnosed with non-dialysis needed chronic kidney disease in stage 4 and 5 (eGFR below 30 ml/min/1,73 m2)
* Of legal age and over 18 of years
* Understand danish and understand the written material
* Able to cooperate about the diet
* Able to take pictures with their phone or willing to learn
Exclusion Criteria
* Pregnant or breast feeding
* Patients with short bowel syndrome, brickre's bladder, pancreatitis or any other known malabsorption problem
* Potassium above 5 mmol/l
* Ongoing infection
18 Years
ALL
No
Sponsors
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Nordsjaellands Hospital
OTHER
University of Copenhagen
OTHER
Responsible Party
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Principal Investigators
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Jens Rikardt Andersen, MD, MPA
Role: STUDY_DIRECTOR
University of Copenhagen
Locations
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Nordshjaellands Hospital
Hillerød, , Denmark
Countries
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Other Identifiers
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H-21069570
Identifier Type: -
Identifier Source: org_study_id