Mesalamine for Uncomplicated Diverticular Disease: a Randomized, Double-blind, Placebo-controlled Study

NCT ID: NCT01627262

Last Updated: 2016-01-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

123 participants

Study Classification

INTERVENTIONAL

Study Start Date

2002-05-31

Study Completion Date

2006-04-30

Brief Summary

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The purpose of this study is to determine whether mesalamine is effective in the treatment of uncomplicated diverticular disease by reducing the pain.

Detailed Description

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Conditions

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Colonic Diverticulosis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Placebo

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

3x1000mg placebo granules per day

Mesalamine

Group Type EXPERIMENTAL

Mesalamine

Intervention Type DRUG

3x1000mg mesalamine granules per day

Interventions

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Mesalamine

3x1000mg mesalamine granules per day

Intervention Type DRUG

Placebo

3x1000mg placebo granules per day

Intervention Type DRUG

Other Intervention Names

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Salofalk granules Placebo granules

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of diverticular disease with acute pain without serious complications
* Lower abdominal pain of moderate or severe intensity at least during the last 4 days before study inclusion

Exclusion Criteria

* Chronic inflammatory bowel disease
* Fever or other signs of serious complications.
Minimum Eligible Age

45 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Dr. Falk Pharma GmbH

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Wolfgang Kruis, MD

Role: PRINCIPAL_INVESTIGATOR

Ev. Krankenhaus Kalk, University of Cologne

Locations

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Ev. Krankenhaus Kalk, University of Cologne

Cologne, , Germany

Site Status

Countries

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Germany

References

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Kruis W, Meier E, Schumacher M, Mickisch O, Greinwald R, Mueller R; German SAG-20 Study Group. Randomised clinical trial: mesalazine (Salofalk granules) for uncomplicated diverticular disease of the colon--a placebo-controlled study. Aliment Pharmacol Ther. 2013 Apr;37(7):680-90. doi: 10.1111/apt.12248. Epub 2013 Feb 17.

Reference Type RESULT
PMID: 23414061 (View on PubMed)

Other Identifiers

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SAG-20/DIV

Identifier Type: -

Identifier Source: org_study_id

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