Mesalamine 2 g Sachet for the Maintenance of Clinical and Endoscopic Remission in Ulcerative Colitis (UC)

NCT ID: NCT02522780

Last Updated: 2021-11-08

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

View full results

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

276 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-02-01

Study Completion Date

2018-09-19

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this trial was to investigate the safety and efficacy of mesalamine 2 g extended release granules (sachet) once a day (QD) for maintenance of clinical and endoscopic remission in subjects with UC. The duration of treatment for each subject was 6 months.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Ulcerative Colitis

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Mesalamine

Mesalamine 2 g extended release granules (sachet), administered orally once daily (QD) for 6 months.

Group Type EXPERIMENTAL

Mesalamine

Intervention Type DRUG

Pharmaceutical form: Granules in sachet; Route of administration: Oral use

Placebo

Placebo matched to mesalamine extended release granules (sachet), administered orally QD for 6 months.

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Pharmaceutical form: Granules in sachet; Route of administration: Oral use

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Mesalamine

Pharmaceutical form: Granules in sachet; Route of administration: Oral use

Intervention Type DRUG

Placebo

Pharmaceutical form: Granules in sachet; Route of administration: Oral use

Intervention Type DRUG

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

Mesalazine Pentasa

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Male or female subjects aged 18 to 75 years, with Ulcerative Colitis in remission

Exclusion Criteria

* Evidence of other forms of inflammatory bowel disease
* Infectious disease (including human immunodeficiency virus \[HIV\], hepatitis B virus \[HBV\], or hepatitis C virus \[HCV\])
* Disease limited to proctitis \<15 cm
* Short bowel syndrome
* Prior colon resection surgery
* History of severe/fulminant UC
* Intolerant or allergic to aspirin or salicylate derivatives
* Use of rectal formulations (5-aminosalicylic acid \[5-ASA\], steroids) within ≤7 days
* Women who are pregnant or nursing
* History of known malignancy
* History of bleeding disorders, active gastric or active duodenal ulcers, autoimmune diseases, or mental/ emotional disorders, that would interfere with their participation in the trial
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Ferring Pharmaceuticals

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Global Clinical Compliance

Role: STUDY_DIRECTOR

Ferring Pharmaceuticals

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Preferred Research Partners

Little Rock, Arkansas, United States

Site Status

United Research Institute

Murrieta, California, United States

Site Status

Research Associates of South Florida, LLC

Miami, Florida, United States

Site Status

IMIC

Palmetto Bay, Florida, United States

Site Status

Medical Research Center of Florida

Pembroke Pines, Florida, United States

Site Status

Lenus Research and Medical Group

Sweetwater, Florida, United States

Site Status

Clinical Trials of SWLA, LLC

Lake Charles, Louisiana, United States

Site Status

Cumberland Research Associates, LLC

Fayetteville, North Carolina, United States

Site Status

Wilmington Gastroenterology Associates

Wilmington, North Carolina, United States

Site Status

Associates in Gastroenterology, PLC

Hermitage, Tennessee, United States

Site Status

Quality Medical Research, PLLC

Nashville, Tennessee, United States

Site Status

BI Research Center

Houston, Texas, United States

Site Status

Biopharma Informatic Inc.

Houston, Texas, United States

Site Status

Digestive Health Center

Pasadena, Texas, United States

Site Status

DM Clinical Research

Tomball, Texas, United States

Site Status

Advanced Research Institute

Ogden, Utah, United States

Site Status

New River Valley Research Institute

Christiansburg, Virginia, United States

Site Status

Digestive & Liver Disease Specialists

Norfolk, Virginia, United States

Site Status

Multiprofile Hospital For Active Treatment Avis Medica

Pleven, , Bulgaria

Site Status

University Multiprofile Hospital for Active Treatment Kaspela

Plovdiv, , Bulgaria

Site Status

Medical Center Excelsior OOD

Sevlievo, , Bulgaria

Site Status

Medical Center-1-Sevlievo EOOD

Sevlievo, , Bulgaria

Site Status

City Clinic University Multiprofile Hospital for Active Treatment EOOD

Sofia, , Bulgaria

Site Status

Medical Center Asklepion - Humane Medicine Research EOOD

Sofia, , Bulgaria

Site Status

University Multiprofile Hospital for Active Treatment Sv Ivan Rilski EAD

Sofia, , Bulgaria

Site Status

University Multiprofile Hospital for Active Treatment Tsaritsa Yoanna - ISUL EAD

Sofia, , Bulgaria

Site Status

Diagnostic Consultative Centre Mladost M OOD

Varna, , Bulgaria

Site Status

Topstone Research Institute

Ottawa, Ontario, Canada

Site Status

Toronto Digestive Disease Associates Inc

Toronto, Vaughan, Canada

Site Status

Magyar Honvédség Egészségügyi Központ

Budapest, , Hungary

Site Status

Pannónia Magánorvosi Centrum Kft

Budapest, , Hungary

Site Status

Semmelweis Egyetem Institute

Budapest, , Hungary

Site Status

Vasútegészségügyi Nonprofit Kiemelten Közhasznú Kft. Debreceni Egészségügyi Központja

Debrecen, , Hungary

Site Status

ENDOMEDIX Kft.

Miskolc, , Hungary

Site Status

Karolina Korhaz Rendelointezet

Mosonmagyaróvár, , Hungary

Site Status

Clinfan Kft.

Szekszárd, , Hungary

Site Status

Polana-D, LTD

Daugavpils, , Latvia

Site Status

Digestive Diseases Centre Gastro

Riga, , Latvia

Site Status

Latvian Maritime Medicine Centre

Riga, , Latvia

Site Status

Pauls Stradins Clinical University Hospital

Riga, , Latvia

Site Status

Riga East Clinical University Hospital

Riga, , Latvia

Site Status

ICARO Investigaciones en Medicina, S.A de C.V

Chihuahua City, , Mexico

Site Status

Maria Auxiliadora Hospital

Guadalajara, , Mexico

Site Status

Investigación Biomédica para el Desarrollo de Fármacos, S.A. de C.V.

Zapopan, , Mexico

Site Status

Osrodek Medycyny Rodzinnej Sp. z o.o.

Sobótka, Lower Silesian Voivodeship, Poland

Site Status

Lexmedica

Wroclaw, Lower Silesian Voivodeship, Poland

Site Status

Zespół Przychodni Specjalistycznych PRIMA Sp. z o.o.

Warsaw, Masovian Voivodeship, Poland

Site Status

Uniwersytecki Szpital Kliniczny w Bialymstoku

Bialystok, Podlaskie Voivodeship, Poland

Site Status

Centrum Badan Klinicznych PI-House sp. z o.o.

Gdansk, Pomeranian Voivodeship, Poland

Site Status

Niepubliczny Zaklad Opieki Zdrowotnej Intermed

Częstochowa, , Poland

Site Status

Economicus - NZOZ ALL-MEDICUS

Katowice, , Poland

Site Status

Investigational site

Ksawerów, , Poland

Site Status

Niepubliczny Zaklad Opieki Zdrowotnej CENTRUM MEDYCZNE Szpital Swietej Rodziny

Lodz, , Poland

Site Status

SPZOZ Uniwersytecki Szpital Kliniczny nr 1 im. Norberta Barlickiego Uniwersytetu Medycznego w Lodzi

Lodz, , Poland

Site Status

Endoskopia Sp. z o.o.

Sopot, , Poland

Site Status

Instytut Pomnik Centrum Zdrowia Dziecka

Warsaw, , Poland

Site Status

Regional Clinical Hospital

Krasnoyarsk, , Russia

Site Status

City Clinical Hospital # 51

Moscow, , Russia

Site Status

Nizhegorodskaya Regional Clinical Hospital n.a. Semashko

Nizhny Novgorod, , Russia

Site Status

Novosibirsk State Medical University

Novosibirsk, , Russia

Site Status

Research Institute of Physiology of Sibirian Branch the RAMS

Novosibirsk, , Russia

Site Status

Omsk State Medical Academy

Omsk, , Russia

Site Status

Rostov State Medical University

Rostov-on-Don, , Russia

Site Status

Ryazan Regional Clinical Hospital

Ryazan, , Russia

Site Status

State Budget Institution of Ryazan region" Regional Clinical Hospital"

Ryazan, , Russia

Site Status

City Hospital #31

Saint Petersburg, , Russia

Site Status

City Polyclinic #38

Saint Petersburg, , Russia

Site Status

Russian Medical Military Academy n.a. S.M. Kirov

Saint Petersburg, , Russia

Site Status

Medical Company "Hepatolog", LLC

Samara, , Russia

Site Status

Stavropol State Medical Academy

Stavropol, , Russia

Site Status

Clinical Hospital Centar Zvezdara

Belgrade, , Serbia

Site Status

Clinical Hospital Center Bezanijska Kosa

Belgrade, , Serbia

Site Status

Health Center Valjevo

Valjevo, , Serbia

Site Status

Inselspital Bern

Bern, , Switzerland

Site Status

Investigational site

Bern, , Switzerland

Site Status

Universitätsspital Zürich

Zurich, , Switzerland

Site Status

Kyiv Municipal Clinical Hospital #18

Kyiv, Kyïv, Ukraine

Site Status

Medical Center LLC Ukrainian German Antiulcer Gastroenterology Center BIK Kyiv

Kyiv, Kyïv, Ukraine

Site Status

Regional Municipal Institution Chernivtsi Regional Clinical Hospital

Chernivtsi, , Ukraine

Site Status

Municipal Institution Dnipropetrovsk Regional Clinical Hospital n.a. I.I. Mechnykov

Dnipropetrovsk, , Ukraine

Site Status

Municipal Healthcare Institution Kharkiv City Clinical Hospital #2

Kharkiv, , Ukraine

Site Status

SI National Institute of Therapy n.a. L.T. Mala of National Academy of Medical Sciences of Ukraine

Kharkiv, , Ukraine

Site Status

Municipal Intitution "Kherson City Clinical Hospital n.a. A. and O. Tropinykh"

Kherson, , Ukraine

Site Status

Private Enterprise Private Manufactire Company "Acinus"

Kirovohrad, , Ukraine

Site Status

Kremenchuk city Hospital # n.a O.T.Bohaievskyi

Kremenchuk, , Ukraine

Site Status

Kyiv City Clinical Hospital #8

Kyiv, , Ukraine

Site Status

Kyiv Municipal Clinical Hospital #18

Kyiv, , Ukraine

Site Status

Medical Center Universal Clinic Oberih of LLC Kapytal

Kyiv, , Ukraine

Site Status

Municipal City Clinical emergency Hospital

Lviv, , Ukraine

Site Status

Municipal Institution Odesa Regional Clinical Hospital

Odesa, , Ukraine

Site Status

Medical Clinical Research Center of Medical Center LLC Health Clinic

Vinnytsia, , Ukraine

Site Status

Small Business Private Enterprise Medical Center "Pulse"

Vinnytsia, , Ukraine

Site Status

Vinnytsia Regional Clinical Hospital Hospital n.a. M.I. Pyrohov

Vinnytsia, , Ukraine

Site Status

Municipal Institution 6th City Clinical Hospital of Zaporizhzhia City Council

Zaporizhzhia, , Ukraine

Site Status

Municipal Institution Zaporizhzhia Regional Clinical Hospital of Zaporizhzhia Regional Council

Zaporizhzhia, , Ukraine

Site Status

Medical Centre of PE First Private Clinic

Zhytomyr, , Ukraine

Site Status

Countries

Review the countries where the study has at least one active or historical site.

Belgium United States Bulgaria Canada Hungary Latvia Mexico Poland Russia Serbia Switzerland Ukraine

Provided Documents

Download supplemental materials such as informed consent forms, study protocols, or participant manuals.

Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

2015-002558-11

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

000175

Identifier Type: -

Identifier Source: org_study_id