TID 1000 mg Mesalazine Versus TID 2x500 mg Mesalazine in Active Ulcerative Colitis (UC)

NCT ID: NCT01745770

Last Updated: 2016-06-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

306 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-01-31

Study Completion Date

2015-06-30

Brief Summary

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The purpose of the trial is to proof whether TID 1000 mg mesalazine is non-inferior to TID 2x 500 mg mesalazine in the treatment of patients with acute ulcerative colitis

Detailed Description

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Conditions

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Active Ulcerative Colitis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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A

Group Type EXPERIMENTAL

Mesalazine - TID 1000 mg

Intervention Type DRUG

B

Group Type ACTIVE_COMPARATOR

Mesalazine - TID 2x 500 mg

Intervention Type DRUG

Interventions

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Mesalazine - TID 1000 mg

Intervention Type DRUG

Mesalazine - TID 2x 500 mg

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Signed informed consent
* Men or women aged 18 to 75 years
* Active ulcerative colitis, except proctitis limited to 15 cm ab ano, confirmed by endoscopy and histology

Exclusion Criteria

* Crohn's disease, indeterminate colitis, ischemic colitis, radiation colitis, diverticular disease associated colitis, microscopic colitis (i.e., collagenous colitis and lymphocytic colitis)
* Toxic megacolon
* Screening stool positive for germs causing bowel disease
* Malabsorption syndromes
* Celiac disease
* Other inflammatory or bleeding disorders of the colon and intestine, or diseases that may cause diarrhoea or gastrointestinal bleeding
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Dr. Falk Pharma GmbH

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Med. Klinik 1 - Markus-Krankenhaus

Frankfurt am Main, Hesse, Germany

Site Status

Countries

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Germany

Other Identifiers

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SAT-25/UCA

Identifier Type: -

Identifier Source: org_study_id

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