Controlled Exposure to Diesel Exhaust in Subjects With Allergic Rhinitis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

14 participants

Study Classification

INTERVENTIONAL

Study Start Date

2001-03-31

Study Completion Date

2002-02-28

Brief Summary

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Proximity to traffic, particularly to diesel-powered heavy-duty vehicles, has been associated with inducing and enhancing allergies in children and adults. To investigate the basis for this association, a controlled exposure of allergic rhinitics to diesel exhaust was performed at a dose known to be pro-inflammatory in healthy individuals.

The hypothesis was that airway inflammation would be augmented in allergic rhinitics following exposure to diesel exhaust at an environmentally pertinent particulate matter concentration.

Fourteen allergic rhinitics were exposed in a double-blinded, randomised trial to both diesel exhaust at 100 microgram/m3 PM10 (representing an aerosol of nanoparticulate combustion particles, mean diameter 80 nm) and filtered air for two hours on separate occasions. Bronchoscopy with endobronchial mucosal biopsies and airway lavage was performed 18 hours post-exposure, and samples were analysed for markers of inflammation.

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Detailed Description

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Conditions

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Allergic Rhinitis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Diesel exhaust

2 hour exposure to diesel exhaust at 100 microgram per cubic meter during intermittent exercise

Group Type EXPERIMENTAL

Bronchoscopy

Intervention Type PROCEDURE

Bronchoscopy with endobronchial biopsy sampling and bronchoalveolar lavage (BAL) 18 hours post exposure. Airway inflammation was assessed.

Filtered air exposure

2 hour exposure to filtered air during intermittent exercise

Group Type EXPERIMENTAL

Bronchoscopy

Intervention Type PROCEDURE

Bronchoscopy with endobronchial biopsy sampling and bronchoalveolar lavage (BAL) 18 hours post exposure. Airway inflammation was assessed.

Interventions

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Bronchoscopy

Bronchoscopy with endobronchial biopsy sampling and bronchoalveolar lavage (BAL) 18 hours post exposure. Airway inflammation was assessed.

Intervention Type PROCEDURE

Other Intervention Names

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Particulate matter Air pollution BAL

Eligibility Criteria

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Inclusion Criteria

* History of seasonal allergic rhinitis requiring medical treatment only during the pollen season and were classified as mild and intermittent according to ARIA guidelines.
* Positive skin prick test to airborne allergens
* Normal lung function
* Negative Metacholine challenge

Exclusion Criteria

* Current smoking or a previous history of smoking.
* Asthma
* Chest infection within six weeks prior to or during the study
* Current use of non-steroidal anti-inflammatory drugs
* Current vitamin C or E supplementation
* Current use of topical nasal steroids.

Minimum Eligible Age

20 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No